The aim of this study was to clarify the risk factors for tooth loss from a physiological, blood biochemical, and nutritional point of view. The subjects of this study were 364 people (224 males, 140 females). They were examinees of a medical examination center in Matsumoto Dental University Hospital. Using the number of teeth present (including sound, decayed, and filled teeth) as the response variable, a multiple regression analysis was conducted using parameters in the mouth, physiological parameters, blood biochemical parameters, and nutritional parameters as covariates. In the multiple regression analysis with the response variable as the number of teeth present, the significant influence of attachment loss, sugar–sweetener intake, age, and sodium intake was noted on a decreasing number of teeth in the study subjects. Thus, the number of teeth present was influenced by the physiological, blood biochemical, and nutritional condition. In the future, increasing the number of cases will be necessary along with long–term follow–up
