Quantum canonical transformations of the second kind and the non-Hermitian realizations of the basic canonical commutation relations are investigated with a special interest in the generalization of the conventional ladder operators. The opeator ordering problem is shown to be resolved when the non-Hermitian realizations for the canonical variables which can not be measured simultaneously with the energy are chosen for the canonical quantizations. Another merit of the non-Hermitian representations is that it naturally allows us to introduce the generalized ladder operators with which one can solve eigenvalue problems quite neatly
