Two rapid, simple and sensitive spectrophotometric methods for the quantitative analysis of ezetimibe (EZB) and
atorvastatin calcium (ATVC) in bulk powder and combined tablet form have been developed and validated. The first
method is bivariate calibration and the second method is ratio subtraction in conjunction with second derivative (D
)spectrophotometry. These methods are tested by analyzing synthetic binary mixtures of the above drugs and they are
applied to commercial pharmaceutical preparation of the subjected drugs. Standard deviation is < 2 in the assay of
raw materials and tablets. Methods are validated as per ICH guidelines and statistical comparison of the suggested
methods with the reported spectrophotometric one using F and t tests showed no significant difference regarding
both accuracy and precision.International Journal of Chemical Studie