This research aims to know the influence of Financing to Deposit Ratio (FDR) against Non Performing Financing (NPF), the influence of Non-Performing Financing (NPF) towards profitability, leverage Financing to Deposit Ratio (FDR) towards profitability , on the Bank of the people's Islamic Financing in Indonesia. The approach used is the quantitative approach using path analysis or path analysis. The sample used in this study is the BPRS from January 2011 to December 2016. The data is drawn from Islamic Banking Statistics issued by Bank Indonesia and the financial services authority totalling 72 data. The results of this study showed that Non Performing Financing (NPF) and the Financing to Deposit Ratio (FDR) influential negative and significantly to Profitability (RoA). Non Performing Financing (NPF) a positive effect towards Profitability (RoA