Kundmannia anatolica HUB.-MOR. and Kundmannia syriaca BOISS. are two endemic species of Apiaceae diversified in Turkey. In the present study, the essential oil composition and antimicrobial activity of these endemic species collected from Southeast Anatolia region of Turkey were investigated. Essentialoils of aerial parts were obtained by hydro distillation method and analyzed by GC–MS/FID. Acetone,chloroform and methanol extracts of aerial parts of the plants were tested against seven bacteria and three yeasts by disc diffusion method for antimicrobial assays and minimum inhibition concentrations(MIC) were determined. Spathulenol, curdione, apritone, germacrene-d and- (−) globulol were the majorcomponents of K. anatolica. In the essential oil of K. syriaca, spathulenol, germacrene-d, bioallethrin,12-norcyercene-B and methadol were determined as the main compounds. The most abundant com-pound of K. anatolica and K. syriaca was spathulenol with 17.40%–19.53% ratio in the GC–MS and 19.7%,24.99% ratio in GC–FID results, respectively. Aerial parts extracts of K. anatolica and K. syriaca exhibitedremarkable antimicrobial activity to all tested microorganisms except for Candida albicans
