Arik Yilmaz, Ebru

Buyuktiryaki, Betul

Cavkaytar, Özlem

Sackesen, Cansin

Sahiner, Umit Murat

Sekerel, Bulent E

Tuncer, Ayfer

Uysal Soyer, Ozge

Yavuz, Suleyman Tolga

Clinical and Translational Allergy

PubMed

Hacettepe University Institutional Repository

Pd41 - Risk Factors For Side Effects During Venom Immunotherapy In Children With Hymenoptera Venom Allergy

Suleyman Tolga Yavuz

Umit Murat Sahiner

Betul Buyuktiryaki

Ebru Arik Yilmaz

Özlem Cavkaytar

Cansin Sackesen

Bulent E Sekerel

Ozge Uysal Soyer

Ayfer Tuncer

Springer - Publisher Connector

POSTER DISCUSSION PRESENTATION Open Access
PD41 - Risk factors for side effects during venom
immunotherapy in children with hymenoptera
venom allergy
Suleyman Tolga Yavuz*, Umit Murat Sahiner, Betul Buyuktiryaki, Ebru Arik Yilmaz, Özlem Cavkaytar,
Cansin Sackesen, Bulent E Sekerel, Ozge Uysal Soyer, Ayfer Tuncer
From 3rd Pediatric Allergy and Asthma Meeting (PAAM)
Athens, Greece. 17-19 October 2013
Background
Since the side effects during Venom Immunotherapy
(VIT) are associated with several risk factors, we aimed
to evaluate the association of serum basal tryptase (sBT)
levels and of other parameters with the frequency of local
and/or systemic reactions during VIT in children.
Method
Children who underwent conventional VIT due to estab-
lished honeybee or wasp allergy and completed 1-year VIT
were included in the study. Data were collected on sBT
levels, age, sex, culprit insect, degree of preceding sting
reaction, time between last preceding sting reaction and
VIT, venom specific IgE concentration, total IgE levels,
accompanying asthma and aeroallergen sensitization.
Results
We enrolled 45 children with a mean ((± standart
deviation) age of 10.0 ± 3.4 years. VIT with wasp venom
was initiated in 39 patients (87%) and with honeybee
venom in 6 patients (13%). Seventeen patients (37.8%) had
encountered lokal or systemic side effects during VIT.
Side effects were present in 41 out of 1448 injections
(2.8%). There was no significant difference at sBT levels of
children with (4.3 µg/L [3.7-6.3]) or without (4.2 µg/L
[3.1-4.7]) side effects (p=0.303). Multivariate logistic
regression analysis revealed presence of asthma (odds
ratio; [95% confidence interval] (14.2 [2.0–123.5]; p=0.008)
as a significant risk factor for side effects during VIT in
children.
Conclusion
Results of our study determined an association between
accompanying asthma and side effects during VIT.
Patients with asthma may need a particularly high degree
of surveillance during VIT procedure.
Published: 28 February 2014
doi:10.1186/2045-7022-4-S1-P41
Cite this article as: Yavuz et al.: PD41 - Risk factors for side effects
during venom immunotherapy in children with hymenoptera venom
allergy. Clinical and Translational Allergy 2014 4(Suppl 1):P41.
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Submit your manuscript at 
www.biomedcentral.com/submitHacettepe University, School of Medicine, Pediatric Allergy and Asthma Unit,
Ankara, Turkey
Yavuz et al. Clinical and Translational Allergy 2014, 4(Suppl 1):P41
http://www.ctajournal.com/content/4/S1/P41
© 2014 Yavuz et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction
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PD41 - Risk factors for side effects during venom immunotherapy in children with hymenoptera venom allergy

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PD41 ‐ Risk factors for side effects during venom immunotherapy in children with hymenoptera venom allergy

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Pd41 - Risk Factors For Side Effects During Venom Immunotherapy In Children With Hymenoptera Venom Allergy

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