Abou-Ayash, S.

Carellis, C.

Kalberer, N. B.

Reissmann, D. R.

Schimmel, M.

Srinivasan, M.

English

Bern Open Repository and Information System (BORIS)

 Does a sage-based mouthwash  improve OHRQoL and Xerostomia  in elders?M. Srinivasan1,2, C. Carellis1,3, D. R. Reissmann4, N. B. Kalberer1,  S. Abou-Ayash3, M. Schimmel2,3  1 Center of General-, Special Care-, & Geriatric Dentistry, University of Zurich, Switzerland2 Division of Gerodontology and Removable Prosthodontics, University Clinics of Dental Medicine, University of Geneva, Switzerland 3 Department of Reconstructive Dentistry and Gerodontology, University of Bern, Bern, Bern, Switzerland4 Department of Prosthetic Dentistry, University Medical Center Hamburg Eppendorf, Hamburg, GermanyObjectivesThe aim of this randomized controlled trial (RCT) was to test whether a sage-based mouthwash improves Oral Health-Related Quality of Life (OHRQoL) and xerostomia-related symptoms com-pared to a placebo. MethodsThis study was ethics approved (Basec-Nr.: 2016-01383) and regis-tered (clinicaltrials.gov: NCT0283080). Potential subjects (inclusion: ≥65 years, dentate) from private practice and long-term-care facilities were included in this randomized, double-blind, placebo-controlled, parallel, clinical trial. Participants were randomly allo- cated into either group A (active agent, Dr. Hauschka Med Mund-spülung Salbei, WALA Heilmittel GmbH, Bad Boll/Eckwälden, Germa-ny; Fig. 1) or group B (taste and color matched custom-fabricated water/alcohol-based placebo). The mouthwash was used once a day for 30 seconds in addition to performing the usual oral hygiene measures, for an intervention period of six weeks. The primary endpoints were the evaluation of OHRQoL and the xerostomia-related impairments using the 14-item German versions of the Oral Health Impact Profile (OHIP-14) and Xerostomia Inventory (XI, 14 items). Linear regression models were applied for the statistical analysis (alpha = 0.05).  ResultsForty-eight subjects were included in the study (mean age = 77.5±7.3 years). Forty-two participants completed the trial and were included for the data analysis (excluded: n = 6, group A = 3, group B = 3; reason for exclusion: incomplete data). Results of linear regression analysis of intervention effect on OHIP-14 and XI summary scores at follow-up, statistically controlled for base-line scores revealed no effect of the intervention (p = 0.521 and p = 0.379, respectively; Tabs. 1 + 2). The XI summary score was highly correlated to the OHIP-14 summary score at baseline and at follow-up (Pearson product moment correlation coefficients: 0.55 and 0.60).ConclusionsThe findings of this study do not indicate that the sage-based mouthwash was better than the placebo in improving the OHRQoL and the xerostomia-related impairments. The results indicate a sufficient convergent validity of the XI to assess a person’s OHRQoL impairments due to xerostomia.Figure 1: Evaluated sage-based mouthwash (active agent; Group A)Table 1: OHIP-14 summary scores at baseline and follow-up for both groups with  corresponding differencesTable 2: XI summary scores at baseline and follow-up for both groups with  corresponding differences#0799Baseline Follow-up DiffMean (SD) Mean (CI) p-value Effect sizeIntervention 0.7 (2.2) 0.5 (1.4) 0.2 (–0.3; 0.7) .463 0.10Control 1.4 (2.1) 1.0 (1.7) 0.4 (–0.8; 1.6) .462 0.22Baseline Follow-up DiffMean (SD) Mean (CI) p-value Effect sizeIntervention 8.9 (11.4) 10.7 (10.0) 1.8 (–0.5; 4.1) .115 0.17Control 7.7 (6.2) 8.2 (10.4) 0.5 (–1.7; 2.6) .652 0.06Acknowledgement: We like to thank Hendrik Jünger (private practice, Laupen Switzerland) and Anna Jaun-Ventrice (private practice, Schwarzenburg, Switzerland) for data collection.source: https://doi.org/10.7892/boris.149483 | downloaded: 4.1.2021

Does a Sage-based Mouthwash Improve OHRQoL and Xerostomia in Elders?

https://boris.unibe.ch/149483/1/3325167_Carellis.pdf

Does a Sage-based Mouthwash Improve OHRQoL and Xerostomia in Elders?

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