Biocompatible polymeric nanoparticles were obtained via thiol-ene polymerization of a biobased monomer in miniemulsion. The α,ω-diene-diester monomer was synthesized through esterification reaction of a glycerol derivative, namely 1,3-propanediol, with 10-undecenoic acid, a long-chain diene carboxylic acid. The biobased poly(thioether-ester), PTEE, nanoparticles were submitted to cytotoxicity and hemolysis analyses. High cell viability and no significant changes in cell morphology were observed. Lastly, hemolysis assays revealed blood compatibility and therefore PTEE nanoparticles have been shown to be a potential alternative drug delivery vector for intravenous administration. The poly(thioether-ester) was also employed to encapsulate magnetic nanoparticles (MNPs) by miniemulsification technique.
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