Synthesis of Ether Backbone RNA NAnalogues and the Development of a Method for Carbohydrate Homologation

Abstract

Carbohydrates having several chiral centers in their structures are potential starting materials for the synthesis of many natural as well as biologically active non-natural products. Monosaccharide is a single carbohydrate unit, and there are some higher-monosaccharide derivatives generally called higher sugars that are not naturally occurring and some of them are very important from biological point of view. This section of the work is primarily comprised of the synthesis of higher sugars (formally C7- C10) starting from lower-membered monosaccharide, D-glucose along with a short review on the reported synthesis of higher sugars. Basically, our synthetic strategy involves with two effective reactions i.e., cross metathesis reaction and Sharpless asymmetric dihydroxylation reaction. The small features of these two reactions have been described in the thesis