Biophysical studies on the interaction of some intercalating and groove binding molecules with deoxyribonucleic acids

Abstract

The mode of action of many drugs in clinical use for the treatment of cancer, genetic disorders and viral diseases is essentially based on their binding to DNA and the subsequent modifications of the genetic material (Hurley et al., 1996; Rezler et al., 2003; Hurley, 2001 and 2002). Therefore, interest in understanding the interaction of small molecule ligands with DNA sequences has been the subject of intense investigations for almost half a century (Waring, 1981) (Chaires, 1998) (Maiti and Kumar, 2007). Despite a large number of DNA binding drugs currently in use in clinics for cancer treatment, selectivity towards malignant cells remains an elusive goal. More detailed knowledge and deeper insights of the DNA interaction ....