Bartuś, Stanisław

Buszman, Paweł

Gąsior, Mariusz

Hiczkiewicz, Jarosław

Kaźmierczak, Jarosław

Kleinork, Andrzej

Lelonek, Małgorzata

Leszek, Przemysław

Niedziela, Jacek T.

Parma, Zofia

Pączek, Piotr

Rozentryt, Piotr

Strojek, Krzysztof

Witkowski, Adam

Zdrojewski, Tomasz

Kardiologia Polska

English

Jagiellonian Univeristy Repository

S H O R T  C O M M U N I C A T I O N  Type 2 diabetes in patients with myocardial infarction 243(PL ‑ACS) contains data on both MI and DM treatment, as well as in ‑hospital and long ‑term outcomes, we decided to analyze the popula‑tion of diabetic patients with MI. The pur‑pose of the study was to compare baseline characteristics, treatment patterns, and in‑‑hospital outcomes of patients with and with‑out DM hospitalized for MI. The second aim was to compare hypoglycemic treatment in pa‑tients with DM with and without left ventric‑ular systolic dysfunction (LVSD) during hos‑pitalization and at discharge.Methods The rationale and methodology of PL ‑ACS were described previously.6 At the time of this analysis, the registry included 738 790 patients with acute coronary syndrome (ACS), of which 456 381 had MI. The study included patients with MI hospitalized between January 2018 and Decem‑ber 2018. They were divided into 2 groups: patients Introduction Diabetes mellitus (DM) is a com‑mon risk ‑factor for cardiovascular diseases. In pa‑tients without a history of cardiovascular disease, DM is associated with a higher risk of coronary ar‑tery disease (CAD), coronary death, and nonfatal myocardial infarction (MI).1 Patients with at least a 10‑year history of DM without any target organ damage and with any risk factor other than DM are categorized as high ‑risk individuals.2 Diabe‑tes may be found in 13.7% to 35.6% of patients with MI and is associated with worse clinical pa‑rameters, higher prevalence of comorbidities, and a greater extent of CAD.2‑5 These patients are also characterized by increased  in ‑hospital mortality, both in men (11.7% in DM vs 7.8% in non ‑DM) and women (15.6% in DM vs 12.6% in non ‑DM).3Proper in ‑hospital treatment and treat‑ment recommended at discharge are of great importance in patients with DM. As the Pol‑ish Registry of Acute Coronary Syndromes Correspondence to: Jacek T. Niedziela, MD, PhD, 3rd Department of Cardiology, Silesian Centre for Heart Disease, ul. M. Curie‑‑Skłodowskiej 9, 41‑800 Zabrze, Poland, phone: +48 32 373 38 60, email: jacek@niedziela.orgReceived: November 6, 2019.Revision accepted: February 10, 2020.Published online: February 12, 2020.Kardiol Pol. 2020; 78 (3): 243‑246doi:10.33963/KP.15189Copyright by the Author(s), 2020S H O R T  C O M M U N I C A T I O NPrevalence, characteristics, and prognostic implications of type 2 diabetes in patients with myocardial infarction The Polish Registry of Acute Coronary Syndromes (PL ‑ACS) annual 2018 reportJacek T. Niedziela1, Jarosław Hiczkiewicz2,3, Andrzej Kleinrok4, Piotr Pączek5, Przemysław Leszek6, Małgorzata Lelonek7, Piotr Rozentryt1,8, Zofia Parma9, Adam Witkowski10, Stanisław Bartuś11, Tomasz Zdrojewski12, Paweł Buszman13, Jarosław Kaźmierczak14, Krzysztof Strojek15, Mariusz Gąsior16 1 3rd Department of Cardiology, Silesian Centre for Heart Disease, Zabrze, Poland 2 Clinical Department of Cardiology, Nowa Sól Multidisciplinary Hospital, Nowa Sól, Poland 3 University of Zielona Góra, Zielona Góra, Poland 4 Department of Cardiology, Pope John Paul II Province Hospital of Zamość, Zamość, Poland 5 Department of Cardiology, Public Clinical Hospital, Sosnowiec, Poland 6 Department of Heart Failure and Transplantology, Cardinal Wyszynski National Institute of Cardiology, Warsaw, Poland 7 Department of Noninvasive Cardiology, Medical University of Łódź, Łódź, Poland 8 Department of Toxicology and Health Protection, School of Public Health, Medical University of Silesia, Bytom, Poland 9 Department of Cardiology and Structural Heart Diseases, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland10 Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland11 Department of Clinical Cardiology and Cardiovascular Interventions Institute of Cardiology, Jagiellonian University Medical College, Kraków, Poland12 Department of Preventive Medicine and Education, Medical University of Gdańsk, Gdańsk, Poland13 American Heart of Poland, Katowice, Poland14 Department of Cardiology, Pomeranian Medical University, Szczecin, Poland15 Department of Internal Diseases Diabetology and Cardiometabolic Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland16 3rd Department of Cardiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, PolandKARDIOLOGIA POLSKA 2020; 78 (3)244in DM patients. No difference in the number of patients treated with PCI was found, while patients with DM had coronary artery bypass grafts and inotropes administered more often and glycoprotein IIb / IIIa inhibitors less often. Although there was no difference in the sec‑ond (other than acetylsalicylic acid) antiplatelet drug use, clopidogrel was used more often in pa‑tients with DM, while ticagrelor, in those with‑out DM. This finding is in contrary to the results of the PLATO (Platelet Inhibition and Clinical Outcomes) study, which showed that ticagre‑lor use was associated with less adverse events in patients with DM and with better survival, with no increase in bleeding.10 This paradox of treating sicker patients with the less effective drug was described before.11 The latest European Society of Cardiology guidelines recommended that patients with and without DM should be treated according to the same antiplatelet strat‑egy, and dual antiplatelet therapy with prasug‑rel or ticagrelor in patients with ACS was supe‑rior to dual antiplatelet therapy with clopido‑grel in both DM and non ‑DM groups.2Patients with DM received at discharge more often: β ‑blockers, renin ‑angiotensin ‑aldosterone system blockers, mineralocorticoid receptor an‑tagonists, diuretics, statins, and nitrates. This might be associated with more advanced age, higher blood pressure, heart rate and lower LVEF. The use of antiplatelet drugs at discharge was similar in both groups.In our study patients with DM had higher oc‑currence of all in ‑hospital adverse events, in‑cluding in ‑hospital death. This observation is consistent with previous studies, in which in‑‑hospital mortality varied between 1.43% (MUL‑TIPRAC) and 9.42% (Belgian STEMI) in patients with DM and ACS and between 0.34% (MULTIP‑RAC) and 6.63% (Belgian STEMI) in those with ACS but no DM.3,5Comparing the hospital treatment of DM in patients with and without LVSD, patients with LVSD received insulin treatment more often, while patients without LVSD, oral antidiabetic drugs. Similar observations were done at dis‑charge. During hospitalizations no differenc‑es in the classes of oral antidiabetic drugs be‑tween the groups were found. Surprisingly, pa‑tients with DM and LVSD were more often dis‑charged without any treatment of DM. Some patients with DM were also treated with thia‑zolidinediones or dipeptidyl peptidase 4 inhib‑itors, which are suspected to play a role in LVSD after MI and are contraindicated in patients with reduced LVEF or at high risk of heart fail‑ure.2,12 Patients with DM and LVSD had higher in ‑hospital mortality than those without LVSD (9.5% vs 2% respectively; P <0.0001).According to the Polish summary of product characteristics of metformin, it is contraindi‑cated in patients with heart failure. However, with DM and those without. Diabetes was defined in the case report form of the registry as history of type 2 diabetes before the hospital admission.Moreover, patients with DM were grouped regarding to LVSD. The cutoff for the diagno‑sis of LVSD was defined as left ventricular ejec‑tion fraction (LVEF) below 40% on the latest in‑‑hospital echocardiography.The study protocol was approved by the eth‑ics committee, and all patients provided writ‑ten informed consent to participate in the study.Statistical analysis Categorical variables were presented as percentages. Continuous vari‑ables with normal distribution were presented as mean (SD) and those with other than normal distribution, as median and interquartile range (IQR). Comparisons between groups were car‑ried out using the t test or the Mann–Whitney test where appropriate. Categorical variables were compared with the χ2 test, with the Bon‑ferroni correction for multiple comparisons and the Yates correction in case of small sample size.Results and discussion We included 25 748 consecutive patients admitted to the hospital with MI between January 2018 and December 2018 who were reported to the PL ‑ACS registry, including 7323 individuals (28.4%) with DM. In other ACS registries, the prevalence of DM var‑ied between 13.7% (MULTIPRAC Registry [Mul‑tinational Non ‑interventional Study of Patients with ST ‑segment Elevation Myocardial Infarc‑tion Treated with Primary Angioplasty and Con‑comitant Use of Upstream Antiplatelet Thera‑py with Prasugrel or Clopidogrel]) and 35.6% (CZECH‑2 Registry).5The baseline characteristics and results were presented in TABLE 1 and Supplementary materi‑al, Table S1. Patients with DM had higher systol‑ic blood pressure, heart rate, body mass index, were more often women, and more often had non–ST‑segment elevation myocardial infarc‑tion.7 The prevalence of comorbidities was high‑er in the group with DM and more smokers were found in the nondiabetic group. These observa‑tions are consistent with other registries.5 Pa‑tients with diabetes had higher levels of glucose, which is considered to be a risk factor regardless of the diabetic or hemodynamic status.8,9 More‑over, patients with DM had higher levels of tri‑glycerides, lower levels of cholesterol, worse kid‑ney function, and lower LVEF. Patients with DM were older than those without DM, which is in line with other ACS registries, in which patients with DM were 64 to 71 years old, and without DM, 61.7 to 67.6 years old.5 This observation may be explained by the fact that in nondiabetic patients, the registered MI was more often the first one (80.2%) compared with patients with DM (68.2%)Multivessel CAD and left main CAD were di‑agnosed more often on coronary angiography S H O R T  C O M M U N I C A T I O N  Type 2 diabetes in patients with myocardial infarction 245TABLE 1 Baseline characteristics, treatment, and outcomes of patients with myocardial infarction and diabetes (continued on the next page)Parameter DM (n = 7323) No DM (n = 18 425) P valueBaseline characteristicsAge, y, mean (SD) 70.6 (10.0) 66.8 (11.7) <0.001Male sex 4254 (58.1) 12 463 (67.6) <0.001Body mass index, kg/m2, median (IQR) 29.4 (6.8) 27.2 (5.7) <0.0001Main symptom of myocardial infarction Chest pain 6093 (83.2); 7321 16 290 (88.5); 18 417 <0.001Dyspnea 682 (9.3); 7321 995 (5.4); 18 417Other 546 (7.5); 7321 1132 (6.1); 18 417ST ‑elevation myocardial infarction 2234 (30.5) 7040 (38.2) <0.001Killip class 1 5669 (77.4) 15 701 (85.3) <0.0012 1134 (15.5) 1975 (10.7)3 312 (4.3) 334 (1.8)4 204 (2.8) 398 (2.2)Systolic blood pressure, mm Hg, median (IQR) 140 (38) 135 (30) <0.001Diastolic blood pressure, mm Hg, median (IQR) 80 (20) 80 (20) 0.09Heart rate, bpm, median (IQR) 78 (20) 75 (19) <0.001Sinus rhythm on admission 6412 (87.7); 7313 16 933 (92); 18 399 <0.001History of arterial hypertension 6290 (87.4); 7197 11 702 (65.3); 17 920 <0.001History of hyperlipidemia 3850 (57.3); 6722 7071 (41); 17 245 <0.001History of coronary artery disease 2435 (34.5); 7057 3506 (19.6); 17 885 <0.001History of myocardial infarction 2267 (31.8); 7128 3724 (19.8); 18 807 <0.001History of PCI 2085 (29.3); 7117 3254 (18); 18 075 <0.001History of CABG 570 (8); 7119 723 (4); 18 081 <0.001History of atrial fibrillation 1308 (18.4); 7095 2043 (11.3); 18 050 <0.001History of stroke 624 (8.8); 7093 849 (4.7); 18 055 <0.001History of heart failure 1143 (17.7); 7024 1600 (8.9); 17 973 <0.001History of chronic kidney disease 1121 (15.8); 7095 1155 (6.4); 18 040 <0.0001Smoking 3404 (55.4); 6149 10 469 (64.1); 16 332 <0.001History of peripheral artery disease 785 (11.2); 7006 965 (5.4); 17 874 <0.001History of cardiac arrest 191 (2.6); 7310 463 (2.5); 18 389 0.66Glucose at admission, mmol/l, median (IQR) 9 (5.7) 6.4 (2.2) <0.001Hemoglobin A1c, %, median (IQR); total 7.2 (2.1); 744 5.7 (0.7); 1187 <0.001Total cholesterol, mmol/l, mean (SD) 4.4 (1.3) 4.9 (1.4) <0.001LDL cholesterol, mmol/l, median (IQR) 2.4 (1.6) 2.9 (1.6) <0.001HDL cholesterol, mmol/l, median (IQR) 1.1 (0.4) 1.2 (0.5) <0.001Triglycerides, mmol/l, median (IQR) 1.5 (1) 1.2 (0.9) <0.001eGFR, ml/min/1.73 m2, median (IQR) 73.2 (47.4) 82.2 (44.6) <0.001LVEF, %, median (IQR) 47 (15) 50 (15) <0.001LVEDD, mm, median (IQR) 51 (7) 50 (8) <0.001LVESD, mm, median (IQR) 37 (10) 35 (9) <0.001NYHA I 3477 (50.3) 10 556 (59.9) <0.001II 2948 (42.6) 6217 (35.3)III 423 (6.1) 743 (4.2)IV 68 (1) 115 (0.6)KARDIOLOGIA POLSKA 2020; 78 (3)246REFERENCES1  Sarwar N, Gao P, Kondapally Seshasai SR, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta‑‑analysis of 102 prospective studies. Lancet. 2010; 375: 2215‑2222.2  Rydén L, Grant PJ, Anker SD, et al. ESC guidelines on diabetes, pre ‑diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J. 2013; 34: 3035‑3087.3  Read SH, Fischbacher CM, Colhoun HM, et al. Trends in incidence and case fa‑tality of acute myocardial infarction, angina and coronary revascularisation in peo‑ple with and without type 2 diabetes in Scotland between 2006 and 2015. Diabe‑tologia. 2019; 62: 418‑425.4  Norhammar A, Tenerz Å, Nilsson G, et al. Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: a pro‑spective study. Lancet. 2002; 359: 2140‑2144.5  Lettino M, Andell P, Zeymer U, et al. Diabetic patients with acute coronary syndromes in contemporary European registries: characteristics and outcomes. Eur Hear J ‑ Cardiovasc Pharmacother. March 2017. [Epub ahead of print].6  Polonski L, Gasior M, Gierlotka M, et al. Polish Registry of Acute Coronary Syn‑dromes (PL ‑ACS). Characteristics, treatments and outcomes of patients with acute coronary syndromes in Poland. Kardiol Pol. 2007; 65: 861‑864.7  Roffi M, Patrono C, Collet J ‑P, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST ‑segment elevation: Task Force for the Management of Acute Coronary Syndromes in Pa‑tients Presenting without Persistent ST ‑Segment Elevation the European Society of Cardiology (ESC). Eur Heart J. 2016; 37: 267‑315.8  Pres D, Gasior M, Strojek K, et al. Blood glucose level on admission determines in ‑hospital and long ‑term mortality in patients with ST ‑segment elevation myocar‑dial infarction complicated by cardiogenic shock treated with percutaneous coro‑nary intervention. Kardiol Pol. 2010; 68: 743‑751.9  Kalińczuk Ł, Zieliński K, Pręgowski J, et al. Higher admission glycaemia inde‑pendently of diagnosed or unrecognised diabetes mellitus is a risk factor for failed myocardial tissue reperfusion and higher mortality after primary angioplasty. Kar‑diol Pol. 2018; 76: 594‑601.10  James S, Angiolillo DJ, Cornel JH, et al. Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: a substudy from the PLATelet inhibi‑tion and patient Outcomes (PLATO) trial. Eur Heart J. 2010; 31: 3006‑3016.11  Ferlini M, Musumeci G, Grieco N, et al. The paradox of clopidogrel use in pa‑tients with acute coronary syndromes and diabetes: Insight from the Diabetes and Acute Coronary Syndrome Registry. Coron Artery Dis. 2018; 29: 309‑315.12  Li JW, Chen YD, Liu YQ, et al. Plasma dipeptidyl ‑peptidase‑4 activity is asso‑ciated with left ventricular systolic function in patients with ST ‑segment elevation myocardial infarction. Sci Rep. 2017; 7: 6097.13  Han Y, Xie H, Liu Y, et al. Effect of metformin on all ‑cause and cardiovascular mortality in patients with coronary artery diseases: a systematic review and an up‑dated meta ‑analysis. Cardiovasc Diabetol. 2019; 18: 96.14  Packer M. Is metformin beneficial for heart failure in patients with type 2 di‑abetes? Diabetes Res Clin Pract. 2018; 136: 168‑170.according the international summary of prod‑uct characteristics, metformin may be used in patients with stable chronic heart failure with a regular monitoring of cardiac and renal func‑tion, while it is contraindicated in patients with acute and unstable heart failure. Accord‑ing to the current European Society of Cardiol‑ogy guidelines, metformin is safe at all stages of heart failure with estimated glomerular filtra‑tion rate greater than 30 ml/min.2 In our study, 51.6% of diabetic patients with MI and LVEF less than 40% had biguanides administered during hospital stay and 24.4% at discharge. Metformin may reduce the risk of cardiovascular events and all ‑cause mortality in patients with MI, as well as heart failure.13 Those benefits are not associat‑ed with the hypoglycemic effects of metformin.14To conclude, patients with DM were older, had more comorbidities, greater CAD extent, and more in ‑hospital events. They received the same (PCI, antiplatelet drugs) or more intensive (oth‑er drug classes) treatment than patients without DM. Patients with DM and LVSD less often re‑ceived oral antidiabetic drugs and more often had insulin or no antidiabetic treatment administered compared with diabetic patients without LVSD.SUPPLEMENTARY MATERIALSupplementary material is available at www.mp.pl/kardiologiapolska.ARTICLE INFORMATIONCONFLICT OF INTEREST  None declared.OPEN ACCESS  This is an Open Access article distributed under the terms of the Creative Commons Attribution ‑NonCommercial ‑NoDerivatives 4.0 In‑ternational License (CC BY ‑NC ‑ND 4.0), allowing third parties to download ar‑ticles and share them with others, provided the original work is properly cited, not changed in any way, distributed under the same license, and used for non‑commercial purposes only. For commercial use, please contact the journal office at kardiologiapolska@ptkardio.pl.HOW TO CITE  Niedziela JT, Hiczkiewicz J, Kleinrok A, et al. Prevalence, charac‑teristics, and prognostic implications of type 2 diabetes in patients with myocardial infarction: the Polish Registry of Acute Coronary Syndromes (PL ‑ACS) annual 2018 report. Kardiol Pol. 2020; 78: 243‑246. doi:10.33963/KP.15189TABLE 1 Baseline characteristics, treatment, and outcomes of patients with myocardial infarction and diabetes (continued from the previous page)Parameter DM (n = 7323) No DM (n = 18 425) P valueIn ‑hospital outcomesPulmonary edema 139 (1.9); 7265 162 (0.9); 18 267 <0.001Cardiogenic shock 166 (2.3); 7265 313 (1.7); 18 267 <0.001Cardiac arrest 223 (3.1); 7263 380 (2.1); 18 267 <0.001Stroke / transient ischemic attack 34 (0.5); 7263 59 (0.3); 18 265 0.1aMajor bleeding 142 (2); 7264 234 (1.3); 18 267 <0.001In ‑hospital mortality 370 (5.1); 7323 625 (3.4); 18 425 <0.001Data are presented as number (percentage); total number of patients for whom data were available unless otherwise indicated.a Yates correctionAbbreviations: CABG, coronary artery bypass graft; DM, diabetes mellitus; eGFR, estimated glomerular filtration rate; HbA1C, glycated hemoglobin; HDL, high ‑density lipids cholesterol; LDL, low ‑density lipids cholesterol; LVEF, left ventricular ejection fraction; LVEDD, left ventricular end diastolic diameter; LVESD, left ventricular end systolic diameter; NYHA, New York Heart Association functional classification

Prevalence, characteristics, and prognostic implications of type 2 diabetes in patients with myocardial infarction : the Polish Registry of Acute Coronary Syndromes (PL-ACS) annual 2018 report

Kleinrok, Andrzej

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Prevalence, characteristics, and prognostic implications of type 2 diabetes in patients with myocardial infarction: the Polish Registry of Acute Coronary Syndromes (PL‑ACS) annual 2018 report

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Prevalence, characteristics, and prognostic implications of type 2 diabetes in patients with myocardial infarction : the Polish Registry of Acute Coronary Syndromes (PL-ACS) annual 2018 report

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