Funder: European Union’s Horizon 2020 Marie Skłodowska – Curie Innovative Training Networks (ITN - ETN) under grant agreement No.: 675712European Union’s Horizon 2020 Marie Skłodowska – Curie Innovative Training Networks (ITN - ETN) under grant agreement No.: 675712 Czech Science Foundation (GA CR), junior project no. 19-23424Y MEYS CZ project CEITEC 2020 (LQ1601)Funder: MEYS CZ project CEITEC 2020 (LQ1601) NCMG research infrastructure (LM22018132 funded by MEYS CR)Funder: European Union’s Horizon 2020 Marie Skłodowska – Curie Innovative Training Networks (ITN - ETN) under grant agreement No.: 675712.Funder: MH CZ-RVO 6526970

Belada, David

Bystry, Vojtech

Fend, Falko

Filip, Daniel

Gambacorti-Passerini, Carlo

Janikova, Andrea

Kamaradova, Katerina

Larose, Hugo

Liang, Huan-Chang

Lobello, Cosimo

Merkel, Olaf

Mologni, Luca

Montes-Mojarro, Ivonne-Aidee

Mraz, Marek

Pospisilova, Sarka

Prokoph, Nina

Radova, Lenka

Sharma, Geeta G.

Tichy, Boris

Turner, Suzanne D.

Apollo (Cambridge)

STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma

Systemic Anaplastic Large Cell Lymphoma (sALCL) encompasses two distinct clinical entities of T-cell non-Hodgkin lymphoma: Anaplastic Lymphoma Kinase-positive (ALK+) ALCL and ALK-negative (ALK-) ALCL. These entities are characterized by either the presence or absence of an ALK-translocation. It has been reported that ALK+ ALCL has a better prognosis compared to ALK-, with a 5-year overall survival (OS) of 70-80% versus 15-45%(1,2). Furthermore, more than 30% of ALK+ ALCL patients relapse(3,4). Despite the distinction between the two sALCL subtypes, frontline treatment for adults is similar and is based on CHOP or CHOEP(5,6). Whilst high-throughput genomic studies in sALCL have shown recurrent genetic alterations, their association with outcome has not been fully investigated(7–11)

Sharma, Geeta G

Turner, Suzanne D

English

STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma.

https://www.repository.cam.ac.uk/bitstream/handle/1810/322053/41375_2020_Article_1093.pdf?sequence=4&isAllowed=y

STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma

Abstract

Similar works

Full text

Available Versions

Apollo (Cambridge)

Apollo (Cambridge)