American Psychiatric Association

Biswaroop Chakrabarty

Gibbs F

Lakshminarayanan Kannan

Panayiotopoulos C

Puneet Jain

Rachna Sehgal

Sharma NL

Sheffali Gulati

 This study describes the clinical characteristics, treatment, and outcome of children with West syndrome in a tertiary care hospital in north India. Overall, 310 case records diagnosed from January 2009 to June 2012 were reviewed. The median age of onset of spasms was 5 months (interquartile range = 2.5-7 months). The predominant underlying etiology was perinatal cerebral ischemia (55%). Adrenocorticotropic hormone or oral steroids were received by 92% children, of whom 43% became seizure free. Median lag time for appropriate treatment initiation was significantly less in patients who became seizure free as compared to those with persisting seizures (11 vs 15 months, P = .001) soon after receiving treatment of choice. Later age at onset of spasms was associated with a favorable seizure outcome ( P = .03). In a resource-limited setting, unawareness along with treatment costs and repeated visits to the hospital are significant obstacles to optimum management. </jats:p

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Journal of Child Neurology

The Clinical Characteristics and Treatment Response in Children with West Syndrome in a Developing Country

The Clinical Characteristics and Treatment Response in Children with West Syndrome in a Developing Country

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