This text is an attempt to analyze fundamental aspects of Gregory of Nyssa’s mystics. In a way of neoplatonic tradition, Gregory speaks on the God as transcendent the world, both – the material and the spiritual, and transcends the human knowledge. God is unknowable. In this kind of understanding, there are two fundamental aspects of Gregory of Nyssa’s conception of mystical experience: ekstasis and epectasis. First, classical in the western kind of mysticism, is known as „a stay beyond the materiality”. Human soul must desert the body and in this way see God. Second, because God is transcendent and unknowable, the human soul must go an unending way to God. It never reaches God Himself.This text is an attempt to analyze fundamental aspects of Gregory of Nyssa’s mystics. In a way of neoplatonic tradition, Gregory speaks on the God as transcendent the world, both – the material and the spiritual, and transcends the human knowledge. God is unknowable. In this kind of understanding, there are two fundamental aspects of Gregory of Nyssa’s conception of mystical experience: ekstasis and epectasis. First, classical in the western kind of mysticism, is known as „a stay beyond the materiality”. Human soul must desert the body and in this way see God. Second, because God is transcendent and unknowable, the human soul must go an unending way to God. It never reaches God Himself