Introduction: Dengue hemorrhagic fever (DHF) caused by the dengue virus carried by Aedes aegypti and Aedes albopictus mosquitoes as a vector to the human body through the bite of the mosquito. Method: Sweet potato leaves taken were made into the dried material and extracted using the percolation method using 70% ethanol until a thick extract is obtained. Tests are carried out microscopically on the dried material. The qualitative identification, testing extracts specific gravity and measurement of total flavonoid levels on the extract. Results: Testing of Specific Parameters observed is organoleptic identity of the extract produced is Color: blackish green, Smell: No smell and Shape: Thick. Qualitative Test with Thin Layer Chromatography, the sample contained flavonoid compounds in flavone and flavonol groups. Total flavonoid levels were measured as equivalent to standard quercetin based on the standard quercetin curve. The result of total flavonoid content from ethanol extract of sweet potato leaves was 31630 mg QE / 100 g extract. Suggestion: Total flavonoid content of 3163mg QE / 100g or 31.63% b / b