ABSTRACT Knowledge of the genetic relationship and admixture among neighbouring livestock populations is crucial for conservation efforts. This study analyzed the molecular diversity of fifteen sheep populations (both indigenous and exotic) in Kenya. Blood samples from 582 individuals were genotyped across the 15 microsatellite markers. The expected heterozygosity and Mean number of alleles ranged from 0.596 to 0.807 and 6.67 to 9.33 respectively. Most populations showed significant heterozygote deficiency due to a moderately high level of inbreeding, f IS (0.109). Population genetic differentiation was reasonably high (θ ST = 0.101). Four population clusters majorly based on geographical proximity and interbreeding among populations were detected. These results indicate levels of admixture warranting institution of conservation measures. However, a more encompassing study including all regions in the country as well as more microsatellite markers is necessary to comprehensively understand the dynamics of genetic introgression
