ABSTRACT Three portable prototype devices for cardiovascular biosensing based on reflection-type photoplethysmography (PPG) principle have been designed and clinically tested. The single-channel PPG finger sensor provides real-time measurements with fast calculation of the mean single-period PPG signal shape ("cardiovascular fingerprint", potentially useful for recognition). The dual-channel PPG system gives additional possibility to monitor on-line the arterial pulse wave transit time and its responses to physical exercises. The four-channel PPG system proved to be applicable for fast detection of cardiovascular pathologies, e.g. arterial occlusions in extremities. Design principles and software algorithms of the regarded devices will be discussed, as well as the results of recent clinical tests