Agaricus blazei Murill (ABM) has traditionally been used as a prevention and cure of several diseases, such as cancer, diabetes, hypertension, immunostimulant, due to its contents such as 1,3-β-D-Glucan, ergosterol, agaritine, tocoferolum, scorbic acid, terpenes. This study is carried out in order to uncover which doses of ABM powder treatment, classified as suitable doses for a healthy condition of experimental animals based on hematological parameters (haemoglobin, erytrocyt, and leucocyt), random blood sugar, cholesterol, and uric acid. This study was an experimental study using experimental animals (rats) treated with ABM powders (three doses) and pure compounds of 1,3-β-DGlucan compared to the control group. Based on all parameter studied, it can be concluded that ABM consumption of 7.2 mg is the most suitable one of dose to be recomended for healthy condition
