ABSTRACT The aim of the present study was to investigate the effect of the methanolic extract of tuberous root of Ipomoea digitata in reducing the cholesterol levels in experimentally induced hyperlipidemic rats. The elevated levels of total cholesterol, ester & free cholesterol, phospholipids, triglycerides, low-density lipoprotein, and very low-density lipoprotein due to HFD. Administration of methanolic extract of Ipomoea digitata (300mg/kg)was significantly (P<0.001)reduced the lipid profile and lipoprotein levels. A significant reduction in HDL-cholesterol was noticed in HFD fed groups (II); however, a significant increased the HDL level was produced by the administration of methanolic extract of Ipomoea digitata (dose 300mg/kg). There was a noticed increase in the body weight in HFD fed group (II), which was reduced by the administration of methanolic extract of Ipomoea digitata (dose 300mg/kg). Therefore, it was concluded that the methanolic extract of tuberous root of Ipomoea digitata has definite cardio protective effect against hyperlipidemia
