Purpose. The purpose of this study was to examine the histochemical distribution of carbonic anhydrase (CA) in lacrimal glands from rats and rabbits; and to determine if age-and/or sex-related differences exist in the amount and distribution of CA in the rat lacrimal gland. Methods. Lacrimal glands from young (3-12 wk) and aged (2-2.5 yr), male and female F344 rats and male rabbits were fixed in 1% paraformaldehyde and embedded in glycolmethacrylate. CA histochemistry was performed on 2-Mm sections. The distribution of CA activity was determined by morphometric analysis
