Abstract : RGD peptides linked with a nonnatural amino acid , phenylazophenyl alaninine (azoAla) , were synthesized and applied to cell adhesion inhibitors. The RGD peptides linked with azoAla at C 2terminal showed potent binding to the integrin on the surface of HeLa cells. Photoisomerization effect of the azobenzene side chain of synthesized peptides on the cell adhesion inhibition was further investigated. It was demonstrated that the cis 2form of azoAla2linked RGD peptides revealed a little weak cell adhesion inhibition effect as compared with trans2form of azoAla2linked RGD peptide
