Abstract Atmospheric emissions from road transport have increased all around the world since 1990 more rapidly than from other pollution sources. Moreover, they contribute to more than 25% of total emissions in the majority of the European Countries. This situation confirms the importance of road transport when complying with emission ceilings (e.g. Kyoto Protocol and National Emissions Ceilings Directive). A methodology has been developed to evaluate the effect of transport measures on atmospheric emissions (EmiTRANS). Its application to Spain in the horizon of 2020 allows the quantification of the effect of several measures on emission reductions. This quantification was done through scenario development. Several scenarios were calculated considering technical measures (e.g. vehicle scrapping systems, higher penetration of hybrid and electric vehicles, fuel substitution, etc.) and non-technical measures (mileage reduction, implementation of Low Emission Zones and/or Congestion Charges in main cities, reduction of average speeds, logistical improvements that affects heavy duty vehicle load factors, etc.). The scenarios show the effect of each measure on NO x , SO 2 , CO, PM 10 , PM 2.5 , VOC, CO 2 and CH 4 emissions. The main conclusion is the necessity to combine both technical and non-technical measures to increase global effectiveness. In the analysis of specific pollutants, there is a great dispersion on reductions effect: technical measures are more effective to reduce air pollutants while non-technical measures are better options to reduce greenhouse effect gases (even though they also reduce air pollutants in a less efficient way)