Solid-Lipid Nanoparticles: A Newer Approach for Formulation and Optmization of HMG-CoA Reductase Inhibitors

Abstract

ABSTRACT The purpose of the study was to formulate the capsules loaded with the Simvastatin solid lipid nanoparticles using the self emulsifying agent, glyceryl monostearate as the source of lipid for incorporation of Simvastatin to form nanoparticles. Development of solid lipid nanoparticles of Simvastatin and to optimize it for independent variables so as to achieve desired particle size with maximum percent entrapment efficiency and percent cumulative drug release. To achieve the goal and formulations were prepared by hot homogenization method and optimized by 2 3 Factorial design (using MET's STAT software). Optimized formulations were freeze dried and its effect on particle size was evaluated. For their entrapment efficiency, drug content, FTIR, DSC, SEM and Invitro drug release study