Objective-Triglyceride-rich lipoproteins that contain apolipoprotein CIII (apoCIII) are prominent in diabetic dyslipidemia. We hypothesized that these lipoproteins increase coronary disease risk in diabetic patients beyond that caused by standard lipid risk factors. Methods and Results-Diabetic patients with previous myocardial infarction were followed for 5 years, and 121 who had a recurrent coronary event were matched to 121 who did not. VLDL and LDL that contained or did not contain apoCIII (CIIIϩ or CIIIϪ) were prepared by immunoaffinity chromatography and ultracentrifugation. apolipoprotein CIII Ⅲ lipoproteins Ⅲ coronary heart disease Ⅲ apolipoprotein E Ⅲ apolipoprotein B P atients with non-insulin-dependent diabetes (NIDDM) have 2 to 3 times higher the risk of coronary heart disease (CHD) than nondiabetic patients. 1-4 Plasma cholesterol, 1,5 LDL cholesterol, 1,5 and HDL cholesterol (HDL-C) 1,5 are strong risk factors for CHD in NIDDM. Diabetic patients have higher plasma triglyceride concentrations than nondiabetic patients. It is not entirely clear whether the high TG concentration contributes independently to CHD in diabetes. In the Paris Prospective Study, TG concentration was an independent predictor in people with impaired glucose tolerance or diabetes even after adjustment for HDL-C and other risk factors. ApoCIII is a small protein on the surface of apoB lipoproteins strongly affecting their metabolism. Alaupovic and colleague
