Behavioral data have shown that attractive faces are better remembered but the neural mechanisms of this effect are largely unknown. To investigate this issue, female participants were scanned with event-related functional MRI (fMRI) while rating the attractiveness of male faces. Memory for the faces was tested after fMRI scanning and was used to identify successful encoding activity (subsequent memory paradigm). As expected, attractive faces were remembered better than other faces. The study yielded three main fMRI findings. First, activity in the right orbitofrontal cortex increased linearly as a function of attractiveness ratings. Second, activity in the left hippocampus increased as a function of subsequent memory (subsequent misses b low confidence hits b high confidence hits). Third, functional connectivity between these orbitofrontal and hippocampal regions was stronger during the encoding of attractive than neutral or unattractive faces. These results suggest that better memory for attractive faces reflects greater interaction between a region associated with reward, the orbitofrontal cortex, and a region associated with successful memory encoding, the hippocampus
