ABSTRACT Investigations were carried out at National Sugar Crops Research Institute (NSCRI), Thatta to assess the performance of different sugarcane genotypes under agro-climatic condition of Thatta during 2006-07. Twelve sugarcane genotypes developed from exotic fuzz (true seed) of USA origin along with one local check as standard variety Thatta-10 were evaluated for their cane yield, yield components and quality performance subsequently in 4 th cycle. The behavior of the genotypes with regard to cane yield, yield components and quality remained variable during the study. The data indicated that the genotypes HoTh-610, HoTh-607 and check variety Thatta-10 remained superior by producing maximum average cane yield of 112.66, 106.66 and 106.00 t ha -1 , respectively. While, the genotypes HoTh-640, HoTh-641 and HoTh-642 were ranked next to check variety on account of producing average cane yield of 103.0, 100.0 and 100.0 t ha -1 , respectively. Moreover, the genotypes HoTh-614, HoTh-612, HoTh-633 and HoTh-618 occupied intermediate position by producing average cane yield of 94.0, 93.00, 89.66 and 82.0 t ha -1 , respectively. While, in case of commercial cane sugar percentage, the data indicated that the genotypes HoTh-642 and HoTh-641were identified as high sugar containing on account of producing maximum CCS of 13.43% and 12.99%, respectively. Moreover, the genotypes HoTh-607, HoTh-606, HoTh-640, HoTh-610 and HoTh-618 also appeared to be the good sugar containing with CCS of 12. 72, 12.42, 12.40, 12.36 and 12.35%, respectively, against Thatta-10 (11.56% CCS). All the genotypes along with Thatta-10 were also less susceptible to borer complex infestation