Abstract: Commercial poultry production is ranked among the highest source of animal protein in the world. Microbial infections caused by bacteria (Salmonella, Clostridium perfringes) and parasites particularly Eimeria has continued to challenge the poultry industry. Antibiotic Growth Promoters (AGP) have been traditionally used to counter microbial infections in poultry. But due to public health concerns, the use of AGP in poultry is either restricted or out rightly banned in several countries. Hence, this review is aimed at highlighting alternative feed supplements that can enhance performance and protect the chickens from microbial infections. The study found that dietary supplements containing probiotic, prebiotic and enzymes are able to enhance performance while protecting the chickens from microbial infection