PHARMACOLOGICAL EVALUATION OF ANTIDEPRESSANT ACTIVITY OF AQUEOUS EXTRACT OF ROSA CENTIFOLIA PETALS IN MICE

Abstract

ABSTRACT To study the antidepressant activity with aqueous extract of Rosa centifolia. The extract was primarily subjected for preliminary phytochemical investigation and for Maximum Tolerance Dose (MTD). Antidepressant activity was evaluated in various animal models like Forced swim test, Tail suspension test, Apomorphine induced hypothermia and 5-HTP potentiation of head twitches in mice. The aqueous extract of Rosa centifolia was positively identified with carbohydrates, tannins, proteins, amino acids, alkaloids, flavonoids, flavanone, glycosides and phenolic compounds. The extract was subjected for maximum tolerance dose upto the dose level of 2000mg/kg has not produced any mortality. The extract of Rosa centifolia showed significant antidepressant activity at high dose (100 mg/kg) in Tail suspension test, Forced swim test and Potentiation of 5-HTP induced head twitches. The extract didn't antagonized the hypothermia induced by apomorphine