Abstract Aim: The aim of our study was to carry out a comparative analysis of the state of development of newborns from Results: This paper provides the characteristics of the state of development of IVF and NP twins on the basis of six somatic features, separately for each sex. The assessment of the overall state of the twins was performed using the Apgar scale. Histopathological examinations concerned the placenta, assessing the degree of morphological-functional disorders. Apart from this, the frequency of incidence of deaths as well as the risk of premature deliveries in both studied groups of twins were also specified. Conclusions: The results obtained by us confirm the thesis that the number and the degree of perinatal complications may be the consequence of multiple pregnancies. The overall state of the twins after in vitro fertilization did not differ from the state of the group of naturally conceived twins. The only confirmed interdependence between in vitro fertilization and perinatal risk occurred in the frequency of newborn deaths