Evaluation of the effects of the anti-retroviral drug regimen (zidovudine + lamivudine + nevirapine) on CD4 count, body weight, and Hb% of the HIV patients-a retrospective study
Abstract The main objective of study is to evaluate the effectiveness of triple drug therapy Zidovudine + lamivudine + nevirapine on cd 4 counts, weight and Hb% for the duration of 6 months. In this retrospective study, data was collected from the anti-retroviral therapy (ART) centre where 315 subjects infected with HIV received ZIDOVUDINE + LAMIVUDINE + NEVIRAPINE. Baseline and after 6 months of therapy; CD4 count, weight and Hb% were recorded and compared. Records with incomplete data were excluded. Statistical analysis was done using paired 't' test for body weight , Hb% and CD4 count.It was found that after 6 months of treatment, both CD4 count and body weight improved significantly(p value: 0.001). Whereas in case of haemoglobin %, even after the treatment period, no significant changes were observed in Hb % (p value: 0.227).It was concluded that ZLN regimen for treatment in HIV patient is efficacious in improving both CD4 count and body weight and not Hb%
