Green Chemistry COMMUNICATION Development of a fluorous, oxime-based palladacycle for microwave-promoted carbon-carbon coupling reactions in aqueous media †

Abstract

A thermally stable, fluorous oxime-based palladacycle has been developed and was shown to efficiently promote various carbon-carbon bond formation reactions (SuzukiMiyaura, Sonogashira and Stille) in aqueous media under microwave irradiation. The palladacycle gave extremely low levels of Pd leaching and could be reused five times with no significant loss of activity. The palladium-catalyzed carbon-carbon coupling reaction is an important tool for the synthesis of symmetric and nonsymmetric biaryls and over the decades, a wide variety of homogeneous catalytic systems have been developed for this transformation