The results from the bile duct-cannulated study revealed that a minimum of 51% of administered dose was absorbed in rats. The pharmacokinetic analysis using unlabeled parent drug showed that Compound I was rapidly absorbed and exhibited a mean apparent terminal half-life of approximately 2.7 h. A total of 15 metabolites of Compound I were detected and profiled in rat urine, bile, and feces. In rat bile, Compound I accounted for <1.5% of the excreted dose, suggesting that Compound I underwent extensively metabolism before elimination. The structures of metabolites were elucidated by high-resolution tandem mass spectrometry. M1, M4, and M6 were the most abundant metabolites observed in rat bile. Only low level of parent [ 14 C]-Compound I was observed in rat plasma. DMD #40980
