SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES STUDY OF SOME AZO DERIVATIEVES OF AMINOTHIADIAZOLE DERIVED FROM NICOTINIC AND ISONICOTINIC ACIDS

Abstract

Abstract In this study we synthesized the new compounds containing bis-1,3,4-thiadiazole 3(A-D) n through many eaction steps (cyclization, diazotiazation and etherification respectively). The compounds have been characterized by melting point, FTIR and 1 HNMR data. All the synthesized compounds have been evaluated in vitro for their antimicrobial activities against several microbes like: Escherichia coli, Klebsiellia pneumonia, Pseudomonas aerugenosa, Serratia marscens and Staphylococcus aureus and the results showed that some of these compounds have very good antibacterial activity