Abstract Season al dyn amics has been studied for a metabolite accumulation in Primula macrocalyx Bge. with respect to its major component, bisbibenzyl riccardin C 1, an inhibitor of inducible NO synthase. Seven introduced populations of the plant have been investigated. A wild-growing P. macrocalyx population was used as a reference. It has been demonstrated the harvesting of plant raw material for the purpose of bisbenzyl 1 isolation is appropriate for carrying out after plant flowering, during the fruiting stage. Besides, in the course of the investigation there were 3′, 4′, 5′-trimethoxyflavone 2 and perrottetin Å 3 isolated from the acetone extract of P. macrocalyx