Abstract: Maternal Mortality in Ghana continues to be a major public health problem despite many strategies devised by the international community to reduce it. The United Nations (UN, 2009) reports indicates that more than 1500 women die each day from pregnancy related causes resulting in an estimated figure of 550,000 maternal deaths annually. This paper applies logistic regression model to determine the key factors that have significant effect to predicting the occurrence or non-occurrence of maternal mortality incidence. An annual maternal mortality data from 2007 to 2012 from Komfo Anokye Teaching Hospital (KATH) was analyzed. The results showed that AGE, PARITY and GRAVIDA contributes significantly to the occurrence of maternal mortality