Abstract: Background: Neonatal Jaundice secondary to isoimmune haemolytic anemia (Rh and ABO incompatibility) is a cause of high serum bilirubin level due to haemolysis of red blood cells secondary to transplacental passage of antibodies. Intravenous immunoglobulins (IVIG) have been successfully used in isoimmune hemolytic jaundice and were found to decrease hemolysis leading to reduction in serum bilirubin level and subsequently decreasing the need for exchange transfusion. Patients and methods: This study was conducted on 30 full term neonates with isoimmune-hemolytic jaundice admitted in the neonatal intensive care units in New Children's hospital, Cairo University. They were randomly classified into 2 groups Group I: "Study group" (15) neonates presented with isoimmune hemolytic jaundice treated by phototherapy + single dose of I.V immunoglobulin infusion (0.5 gm/Kg). Group II: "Control group"
