Simultaneous Screening of Activities of Five Cytochrome P450 and Four Uridine 59-Diphospho-glucuronosyltransferase Enzymes in Human Liver Microsomes Using Cocktail Incubation and Liquid Chromatography-Tandem Mass Spectrometry s

Abstract

ABSTRACT Cytochrome P450 (P450) and uridine 59-diphospho-glucuronosyltransferase (UGT) are major metabolizing enzymes in the biotransformation of most drugs. Altered P450 and UGT activities are a potential cause of adverse drug-drug interaction