Abstract Learning is a process that needs hardwork and sometimes makes students frustrated and get bored. In this context, the use of computers as media in teaching-learning process is of important to attract students' attention and to make teaching-learning activities more effective and enjoyable. This study aimed at designing computerassisted instruction of high-level plant anatomy to support the 5 th grade of elementary schools students' learning outcomes. To design the model, we employed a qualitative approach using developmental research design. Results of this present study are follows: [a] computer-assisted instruction of the structures of monocot (monocotyledon) and dicot (dicotyledon) plants; (b) computer-assisted instruction of the tissues' function of monocot (monocotyledon) and dicot (dicotyledon) plants. Since the use of computers in teaching-learning process is still lack in Merauke context, the results of this present study might be also worthwhile for the Head of Education Office at government level to provide LCD projectors for schools to promote the use of computer in teaching-learning process. The results of this present study might be imperative for the schools' principals to support teachers in designing computerassisted instruction in order that students are motivated to enthusiastically learn all the subjects