Abstract: The present investigation was performed to examine the effect of some herbal food plants (black seeds, curcumin roots, flax seeds and garlic at a level of 20 % on liver enzymes function and lipids profile in hypercholesterolemic rats model on modifying some metabolic parameters. Fourty two male male adult Wistar albino rats weighing initial mean body weight of approximately 120 ± 10g were used. The rats were divided into six groups of seven rats each with similar mean total weight. Group 1 served as normal control fed the balance diet at 14% protein level. The five groups rats were fed the the balance diet and high fat high cholesterol diet (HFHCD) at 1% cholesterol with 5% hump fat. Group 2 served as positive control. Groups 3, 4, 5 and 6 fed (HFHCD) with different types of tested herbal food plants (black seeds, curcumin roots, flax seeds and garlic at 20% level) for five weeks. Food and water were provided ad-libitum. At the end of the experiment, rats were sacrificed under ether anesthesia and blood sample was taken from orbitoocular vein from each rat. Blood samples were subjected to the determination of fasting blood glucose, serum lipid profile, serum protein and albumin, serum ALT, AST, GGT ,bilirubin, creatinine and urea. The results indicated that different types of tested herbal plants had a great effect in all parametars studied. Each of the herbal food proved to be effective to a greater extent in modifying the metabolic parameters, as compared with positive control group. Diets containing flax seed could be scored as the highest in term of modification of the metabolic parameters, from the qualitative and quantitative point of vie
