Antidiabetic Studies of Dihydropyrimido[4,5-a]acridin-2-amines

Abstract

An in vitro antidiabetic activity on -amylase and -glucosidase activity of novel 10-chloro-4-(2-chlorophenyl)-12-phenyl-5,6-dihydropyrimido[4,5-a]acridin-2-amines (3a-3f) were evaluated. Structures of the synthesized molecules were studied by FT-IR, 1 H NMR, 13 C NMR, EI-MS, and single crystal X-ray structural analysis data. An in silico molecular docking was performed on synthesized molecules (3a-3f). Overall studies indicate that compound 3e is a promising compound leading to the development of selective inhibition of -amylase and -glucosidase