Du Jinhang

Meselhy Ragab  Meselhy  Zayed

Nguyen Minh  Khoi

Rungpetch C.  Sakulbumrungsil

Shao-Qing CAI

合田 幸広

川原 信夫

紺野 勝弘

University of Toyama Repository

研究開発部門Department of Research and Development客員教授　　　　Shao-Qing CAI客員教授　　　　Rungpetch C. Sakulbumrungsil客員教授　　　　Meselhy Ragab Meselhy Zayed客員教授　　　　合田　幸広客員教授　　　　川原　信夫客員教授　　　　紺野　勝弘客員教授　（前）　Nguyen Minh Khoi客員教授　（前）　Du Jinhang◆	 原　著1) Aki Kohyama, Rei Yokoyama, Dya Fita Dibwe, Sahar El-Mekkawy, Meselhy R Meselhy, Suresh Awale, Yuji Matsuya. Synthesis of guggulsterone derivatives as potential anti-austerity agents against PANC-1 human pancreatic cancer cells. Bioorg Med Chem Lett. 2020 Apr 1; 30(7): 126964. doi: 10.1016/j.bmcl.2020.126964. 2) Yasmine F. Madi, Mouchira A.Choucry, Salma A.El-Marasy, Meselhy R.Meselhy, El-Sayeda A.El-Kashoury. UPLC-Orbitrap HRMS metabolic profiling of Cymbopogon citratus cultivated in Egypt; neuroprotective effect against AlCl 3-induced neurotoxicity in rats. J Ethnopharmacol. 2020 Sep 15; 259: 112930. doi: 10.1016/j.jep.2020.112930. 3) Ayat M Emad, Sherifa F Ali, Engy A Abdel-Rahman, Meselhy R Meselhy, Mohamed A Farag, Sameh S Ali, Essam A Abdel-Sattar. Anti-inflammatory and antioxidant effects of Apium graveolens L. extracts mitigate against fatal acetaminophen-induced acute liver toxicity. J Food Biochem. 2020 Jul 26; e13399. doi: 10.1111/jfbc.13399. 4) Shuai Huang, Feng Xu, Yin-Ye Wang, Ming-Ying Shang, Chao-Qun Wang, Xuan Wang, Shao-Qing Cai. Improvement and Application of Acute Blood Stasis Rat Model Aligned with the 3Rs (Reduction, Refinement and Replacement) of Humane Animal Experimentation. Chin J Integr Med. 2020 Apr; 26: 292-298. doi: 10.1007/s11655-014-2008-y. 5) Batsukh Z., Toume K., Javzan B., Kazuma K., Cai S.Q., Hayashi S., Atsumi T.,Yoshitomi T, Uchiyama N., Maruyama T., Kawahara N., Komatsu K. Characterization of metabolites in Saposhnikovia divaricata root from Mongolia. J Nat Med. doi: 10.1007/s11418-020-01430-9. Epub 2020 Aug 1. 6) Gegentana, Feng Xu, Feng-Chun Li, Yi-Fan Zhang, Shu-Jie Shen, Ping Yang, Xin-Xin Yang, Ming-Ying Shang, Guang-Xue Liu, Yao-Li Li, XuanWang, Shao-Qing Cai. Discovery of the active compounds of Smilacis Glabrae Rhizoma by utilizing the relationship between the individual differences in blood drug concentration and the pharmacological effect in rats. J Ethnopharmacol. 2020 Aug 10; 258: 112886. doi: 10.1016/j.jep.2020.112886. 7) Guang-Xue Liu, Feng Xu, Ming-Ying Shang, Xuan Wang, Shao-Qing Cai. The Relative Content and Distribution of Absorbed Volatile Organic Compounds in Rats Administered Asari Radix et Rhizoma Are Different between Powder- and Decoction-Treated Groups. Molecules. 2020 Sep 27; 25(19): 4441. doi: 10.3390/molecules25194441. 8) El-Sawi SA,Ezzat SM,Aly HF, Merghany RM, Meselhy MR. Neuroprotective effect of Salvia splendens extract and its constituents against AlCl3-induced Alzheimer's disease in rats. ADVANCES IN TRADITIONAL MEDICINE. 2020 Sep; 20(3): 381-393. doi: 10.1007/s13596-019-00421-w. 9) Li HF, Li T, Yang P, Wang Y, Tang XJ, Liu LJ, Xu F, Shang MY, Liu GX, Li YL, Wang X, Yin J, Cai SQ. Global Profiling and Structural Characterization of Metabolites of Ononin Using HPLC-ESI-IT-TOF-MS n After Oral Administration to Rats. J Agric Food Chem. 2020 Dec; 68(51): 15164-15175. doi: 10.1021/acs.jafc.0c04247. 10) Liu LJ, Li HF, Xu F, Wang HY, Zhang YF, Liu GX, Shang MY, Wang X, Cai SQ. Exploring the In Vivo Existence Forms (23 Original Constituents and 147 Metabolites) of Astragali Radix Total Flavonoids and Their Distributions in Rats Using HPLC-DAD-ESI-IT-TOF-MSn. Molecules. 2020 Nov 26; 25(23): 5560. doi: 10.3390/molecules25235560. 11) Suwannaprom P, Suttajit S, Eakanunkul S, Supapaan T, Kessomboon N, Udomaksorn K, Sakulbumrungsil R. Development 国際共同研究分野Division of International Cooperative Research和漢医薬学総合研究所− 237 −of pharmacy competency framework for the changing demands of Thailand's pharmaceutical and health services. Pharm Pract (Granada). 2020 Oct; 18(4): 2141. doi: 10.18549/PharmPract.2020.4.2141. 12) Rádis-Baptista G., Dodou H.V., Prieto-da-Silva Á.R.B., Zaharenko A.J., Kazuma K.,Nihei K., Inagaki H., Mori-Yasumoto K., Konno K. Comprehensive analysis of peptides and low molecular weight components of the giant ant Dinoponera quadriceps venom. Biol. Chem. 2020 Jul 28; 401(8): 945-954. doi: 10.1515/hsz-2019-0397. 13) Hyuga S., Hyuga M., Amakura Y., Yangi J., Mori E., Hakamatsuka T., Goda Y., Odaguchi H., Hanawa T. Effect of Ephedra Herb on Erlotinib Resistance in c-Met-Overexpressing Non-Small-Cell Lung Cancer Cell Line, H1993, through Promotion of Endocytosis and Degradation of c-Met. Evid.-Based Complementary Altern. Med. 2020 Apr; 2020: 7184129. doi: 10.1155/2020/7184129. 14) Yoshida H., Usui A., Abe Y., Goda Y., Izutsu K.-i. Relationship Between Geometric and Aerodynamic Particle Size Distributions in the Formulation of Solution and Suspension Metered-Dose Inhalers. AAPS. PharmSciTech. 2020 May; 21(5): 158. doi: 10.1208/s12249-020-01675-3. 15) Uchiyama N., Hosoe J., Miura T., Sugimoto N., Ishizuki K., Yamada Y., Iwamoto Y., Suematsu T., Komatsu T., Maruyama T., Igarashi Y., Higano T., Shimada N., Goda Y. Determination of Absolute Purities of Hygroscopic Substances by Quantitative NMR Analysis for the Standardization of Quantitative Reagents in the Japanese Pharmacopoeia (Part 1). Yakugaku Zasshi. 2020 Apr; 140(8): 1063-1069. doi: 10.1248/yakushi.20-00066. 16) Takechi-Haraya Y., Goda Y., Izutsu K.-i., Sakai-Kato K. Instrument-Dependent Factors Affecting the Precision in the Atomic Force Microscopy Stiffness Measurement of Nanoscale Liposomes. Chem. Pharm. Bull. 2020; 68(5): 473-478. doi: 10.1248/cpb.c20-00067. 17) Miyazaki T., Kanno H., Yamamoto E., Ando D., Izutsu K.-i., Goda Y. Cold Flow Evaluation in Transdermal Drug Delivery Systems by Measuring the Width of the Oozed Adhesive. AAPS. PharmSciTech. 2020 Apr; 21(4): 120. doi: 10.1208/s12249-020-01661-9. 18) Miura T., Sugimoto N., Bhavaraju S., Yamazaki T., Nishizaki Y., Liu Y., Bzhelyansky A., Amezcua C., Ray J., Zailer E., Diehl B., Gallo V., Todisco S., Ofuji K., Fujita K., Higano T., Geletneky C., Hausler T., Singh N., Yamamoto K., Kato T., Sawa R., Watanabe R., Iwamoto Y., Goda Y. Collaborative Study to Validate Purity Determination by 1 H Quantitative NMR Spectroscopy by Using Internal Calibration Methodology. Chem. Pharm. Bull. 2020 Sep; 68(9): 868-878. doi: 10.1248/cpb.c20-00336. 19) Ishii-Watabe A., Shibata H., Suetomo H., Ikeda Y., Telikepalli S., Kiyoshi M., Hayashi Y., Muto T., Tanaka Y., Ueda S., Iwura T., Saitoh S., Aoyama M., Harazono A., Hyuga M., Goda Y., Torisu T., Uchiyama S. Recent Achievements and Current Interests in Research on the Characterization and Quality Control of Biopharmaceuticals in Japan. J. Pharm. Sci. 2020 May; 109(5): 1652-1661. doi: 10.1016/j.xphs.2020.01.001. 20) Hakamazuka T., Kamakura H., Watanabe J., katori Y., Matsumoto K., Ishimaru M., Morota T., Goda Y. Bioequivalence Test between Kakkonto Extract Granules and Tablets in Healthy Volunteers. Shoyakugaku Zasshi. 2020; 74: 89-97. 21) Goda Y. Role and expected future development of the Japanese Pharmacopoeia. Yakugaku Zasshi. 2020; 140(6): 759-761. doi: 10.1248/yakushi.19-00253-1. 22) Fujii I., Hashimoto M., Konishi K., Unezawa A., Sakuraba H., Suzuki K., Tsushima H., Iwasaki M., Yoshida S., Kudo A., Fujita R., Hichiwa A., Saito K., Asano T., Ishikawa J., Wakana D., Goda Y., Watanabe A., Watanabe M., Masumoto Y., Kanazawa J., Sato H., Uchiyama M. Shimalactone Biosynthesis Involves Spontaneous Double Bicyclo-Ring Formation with 8π-6π Electrocyclization. Angew. Chem. Int. Ed. 2020 May; 59(22): 8464-8470. doi: 10.1002/anie.202001024. 23) Abe Y., Yamamoto E., Yoshida H., Usui A., Tomita N., Kanno H., Masada S., Yokoo H., Tsuji G., Uchiyama N., Hakamatsuka T., Demizu Y., Izutsu K.-i., Goda Y., Okuda H. Temperature-Dependent Formation of N-Nitrosodimethylamine during the Storage of Ranitidine Reagent Powders and Tablets. Chem. Pharm. Bull. 2020 Oct; 68(10): 1008-1012. doi: 10.1248/cpb.c20-00431. 24) Yoshida K., Teppabut Y., Sawaguchi R., Nakane Y., Hayashi E., Oyama K.-i., Nishizaki Y., Goda Y., Kondo T. 5,7,3',4'-Tetrahydroxyflav-2-en-3-ol 3-O-glucoside, a new biosynthetic precursor of cyanidin 3-O-glucoside in the seed coat of black soybean, Glycine max. Sci. Rep. 2020 Oct; 10(1): 17184. doi: 10.1038/s41598-020-74098-6. 25) Izutsu K.-i., Usui A., Yamamoto E., Abe Y., Yoshida H., Goda Y. Effect of Complex Coacervation with Hyaluronic Acid on Protein Transition in a Subcutaneous Injection Site Model System. Chem. Pharm. Bull. 2020 Nov; 68(11): 1109-1112. doi: 10.1248/cpb.c20-00585. − 238 −26) Uchiyama N., Hosoe J., Sugimoto N., Ishizuki K., Koide T., Murabayashi M., Miyashita N., Kobayashi K., Fujimine Y., Yokose T., Ofuji K., Shimizu H., Hasebe T., Asai Y., Ena E., Kikuchi J., Kiyota K., Fujita K., Makino Y., Yasobu N., Yamada Y., Iwamoto Y., Miura T., Mizui K., Asakura K., Suematsu T., Kohama A., Goda Y. Absolute Purity Determination of a Hygroscopic Substance, Indocyanine Green, Using Quantitative NMR (qNMR). Chem. Pharm. Bull. doi: 10.1248/cpb.c20-00728. Epub 2020 Oct 22.27) Hirasawa Y., Agawa-Kakimoto M., Zaima K., Uchiyama N., Goda Y., Morita H. Complanadine F, a novel dimeric alkaloid from Lycopodium complanatum. J. Nat. Med. doi: 10.1007/s11418-020-01476-9. 28) Uchiyama N., Hosoe J., Miura T., Sugimoto N., Ishizuki K., Yamada Y., Iwamoto Y., Suematsu T., Komatsu T., Maruyama T., Igarashi Y., Higano T., Shimada N., Goda Y. Determination of Absolute Purities of Hygroscopic Substances by Quantitative NMR Analysis for the Standardization of Quantitative Reagents in the Japanese Pharmacopoeia (Part 2). Chem. Pharm. Bull. ; 69(1): 26-31. doi: 10.1248/cpb.c20-00296. 29) Yamamoto E., Taquahashi Y., Kuwagata M., Saito H., Matsushita K., Toyoda T., Sato F., Kitajima S., Ogawa K., Izutsu K.-i., Saito Y., Hirabayashi Y., Iimura Y., Honma M., Okuda H., Goda Y. Visualizing the spatial localization of ciclesonide and its metabolites in rat lungs after inhalation of 1-μm aerosol of ciclesonide by desorption electrospray ionization-time of flight mass spectrometry imaging. Int. J. Pharm. 120241. doi: 10.1016/j.ijpharm.2021.120241. 30) Yoshitomi T., Wakana D., Uchiyama N., Tsujimoto T., Kawano N., Yokokura T.,Yamamoto Y., Fuchino H., Hakamatsuka T., Komatsu K., Kawahara N., Maruyama T. Identifying the compounds that can distinguish between Saposhnikovia root and its substitute, Peucedanum ledebourielloides root, using LC-HR/MS metabolomics. J. Nat. Med. 2020 Jun; 74(3): 550-560. doi: 10.1007/s11418-020-01409-6. 31) Arita M., Fuchino H., Kawakami H., Ezaki M., Kawahara N. Characterization of a New Antienterovirus D68 Compound Purified from Avocado. ACS. Infect. Dis. 2020 Aug; 6(8): 2291-2300. doi: 10.1021/acsinfecdis.0c00404. 32) Matsumoto T., Tanaka D., Yoshimatsu K., Kawano N., Kawahara N., Maki S., Yamamoto S., Niino T. Application of cryobanking for Platycodon grandiflorum in vitro axillary buds using cryo-plate methods. In Vitro Cell. Dev. Biol. Plant. 2020 Sep; doi: 10.1007/s11627-020-10119-3. 33) Yoshimatsu K., Kawano N., Nozaki K., Tsubota K., Kawahara N. Development of efficient micropropagation system in Cinnamomum cassia Blume through plant tissue culture. Aroma Res. 2020; 21(3): 211-219. doi: . 34) Yang L., Kirikoshi J., Sato D., Takasugi M., Hishida A., Hayashi S., Kawahara N.,Mizukami M., Wu M., Yamagishi T., Arai H. New isoflavone glucosides in yabumame (Amphicarpaea bracteata (L.) Fernald subsp. edgeworthii (Benth.) H.Ohashi var.japonica (Oliv.) H.Ohashi) and their effect on leukotriene B4 production in mast cells. J. Nat. Med. doi: 10.1007/s11418-020-01439-0. Epub 2020 Aug 16. 35) Kawakami H, Fuchino H, Kawahara N. Endotoxin Contamination and Reaction Interfering Substances in the Plant Extract Library. Biol., Pharm., Bull. 2020; 43(11): 1767-1775. doi: 10.1248/bpb.b20-00489. 36) Nose M., Tsutsui R., Hisaka S., Akiyama H., Inui T., Kawano N., Hayashi S., Hishida A., Fuchino H., Kudo T., Kawahara N., Yoshimatsu K. Evaluation of the safety and efficacy of Glycyrrhiza uralensis root extracts produced using artificial hydroponic and artificial hydroponic-field hybrid cultivation systems III: anti-allergic effects of hot water extracts on IgE-mediated immediate hypersensitivity in mice. J Nat Med. 2020; 74(2): 463-466. doi: 10.1007/s11418-019-01378-5. 和漢医薬学総合研究所− 239 −

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