ABSTRACT The impeding safety challenges to the use of herbs have made qualitative and quantitative evaluation of herbal preparations a necessity. This study was aimed at evaluating the pharmacognostic and pharmacological properties of V. amygdalina leaf. Methods used include standard procedure for macroscopic and microscopic examinations; ash and extractive values determination; and quantitative evaluation of phytochemicals of the leaf aqueous extract. 4-day antiplasmodial suppression test using mice and antipyretic evaluation in rats induced pyrexia by i.p administration of 15% and dose induced body temperature decrease, were significant (P ≤ 0.05) for all the 3 dose levels of the extract used. Study agrees with folkloric use of the leaf extract in malaria fever but suggests substantial antipyretic property of the leaf