森 佳洋

水口 峰之

篠田 裕之

水口, 峰之

森, 佳洋

篠田, 裕之

University of Toyama Repository

????? Physical Pharmacy ???????? Structural Biology  ???   ?? ??   Mineyuki Mizuguchi ? ?   ?  ??   Yoshihiro Mori ? ?   ?? ??   Hiroyuki Shinoda  ? ? ? 1)  ??????????NMR???????????????. ???????????????????????????????????, ????? ???, ?????????, ??, 652-656, 2004?    ? ? ? 1)  Matsubara, K., Mizuguchi, M., Igarashi, K., Shinohara, Y., Takeuchi, M., Matsuura, A., Saitoh, T., Mori, Y., Shinoda H. and Kawano, K. :Dimeric transthyretin variant assembles into spherical neurotoxins. Biochemistry, 44: 3280-3288, 2005.   2)  Nakamura, T., Takasugi, H., Aizawa, T., Yoshida, M., Mizuguchi, M., Mori, Y., Shinoda, H., Hayakawa, Y. and Kawano, K. :Peptide mimics of epidermal growth factor (EGF) with antagonistic activity. Journal of Biotechnology, 116: 211-219, 2005. 3)  Kondou, Y., Kitazawa, D., Takeda, S., Yamashita, E., Mizuguchi, M., Kawano, K. and Tsukihara, T. :Crystallization and preliminary X-ray analysis of gene product 44 from bacteriophage Mu. Acta Crystallographica, F61: 104-105, 2005. 4)  Kouno, T., Mizuguchi, M., Tanida, I., Ueno, T., Kanematsu, T., Mori, Y., Shinoda, H., Hirata, M., Kominami, E. and Kawano, K. :Solution structure of MAP-LC3 and identification of its functional subdomains. Journal of Biological Chemistry, 280: 24610-24617, 2005.   5)  Mizuguchi, M., Matsuura, A., Nabeshima, Y., Masaki, K., Watanabe, M., Aizawa, T., Demura, M., Nitta, K., Mori, Y., Shinoda, H. and Kawano, K. :Effects of the stabilization of the molten globule state on the folding mechanism of α-lactalbumin: a study of a chimera of bovine and human α-lactalbumin. PROTEINS: Structure, Function, and Bioinformatics, 61: 356-365, 2005.   6)  Kubo, M., Sato, M., Aizawa, T., Kojima, C., Kamo, N., Mizuguchi, M., Kawano, K. and Demura, M. :Disassembling and bleaching of chloride-free pharaonis halorhodopsin by octyl-beta-glucoside. Biochemistry, 44: 12923-12931, 2005.   7)  Kondou, Y., Kitazawa, D., Takeda, S., Tsuchiya, Y., Yamashita, E., Mizuguchi, M., Kawano, K. and Tsukihara, T. :Structure of the central hub of bacteriophage Mu baseplate determined by X-ray crystallography of gp44. Journal of Molecular Biology, 352: 976-985, 2005. 8)  Shinoda, H., Mori, Y., Kitagawa, T. and Kawano, K. :Ab initio MO computation of the hydration effect on the ionization potential of sodium pyrenesulfonate. Journal of Molecular Structure (THEOCHEM), 715: 205-214, 2005. 9)  Shinoda, H., Sayama, M., Mori, Y. and Mizuguchi, M. :Ab initio computations for the ring-opening potential of propylene oxide: roles of a proton and a water molecule. Internet Electronic Journal of Molecular Design, 4: 698-710, 2005.    ? ???? 1)  Kouno T., Mizuguchi M., Tanida I., Ueno T., Kominami E. and Kawano K. :Structure and function of the subdomains of MAP-LC3. XXI International Conference on Magnetic Resonance in Biological Systems, 2004, January 16-21, Hyderabad, India. 2)  Yoshida M., Shitara K., Matsubara K., Kouno T., Aizawa T., Hayakawa Y., Kumaki Y., Mizuguchi M., Demura M., Nitta K. and Kawano K. :Contribution of flexible N-terminal residues to the biological activity of insect cytokine, growth-blocking peptide (GBP). 3rd International and 28th European Peptide Symposium, 2004, September 5-10, Prague, Czech Republic. 3)  Kouno T., Mizuguchi M., Tanida I., Ueno T., Kominami E. and Kawano K. :Solution structure of MAP-LC3 and identification of its functional subdomains. ICSG2004(International conference on structural genomics), 2004, November 17-21, Washington DC, USA. 4)  ??????????????????????????????????????PDCD5? NMR???????????????? 125???2005, 3? 29??3? 31?????????????????????????????? 5)  ?????????????????????????????????????????????????????????????????????? 125???2005, 3? 29??3? 31??????????????????????????????? 6)  ?? ?????????????????????????????????????????????????? GBP?????? C???????????????????? 5????????????2005, 6? 30??7? 2?????????? 7)  ???????????????????????????????????????????????. ? 5 ????????????2005, 6? 30??7? 2?????????? 8)  ??????????????????????????????????pH2.0 ???????????????????????????. ? 5????????????2005, 6? 30??7? 2?????????? 9)  Sugaya T., Mizuguchi M., Nakamura T., Kouno T., Kawano K. :Solution structure of PDCD5, an important regulator in both apoptoic and non-apoptoic programmed cell death. The 19th Symposium of Protein Society, 2005, July 30-August 3, Boston, USA. 10)  ???????????????????????The C-terminal domain of PQBP-1 is a functional unfolded domain. ?78?????????, 2005, 10? 19??22?, ???????????????? 11)  Kouno T., Mizuguchi M., Mori Y., Tanida I., Ueno T., Kominami E., Kawano K. :Observation of protein binding to membrane with photo-CIDNP technique. ? 44? NMR????? 1??????? NMR???????????2005? 11?8??11???????????????? 12)  Umetsu Y., Aizawa T., Muto K., Yamamoto H., Mizuguchi M., Demura M., Nitta K., Hayakawa Y., Kawano K. :The effects on the structure and activity of growth-blocking peptide by C-terminal elongation with parasitism. ? 44? NMR????? 1??????? NMR???????????2005? 11? 8??11???????????????? 13)  ?? ???? ????? ????? ????? ???? ????? ????? ???Drosophila melanogaster??????? roadblock? NMR??????????????????? 43????2005? 11? 23??25???????????????? 14)  ??????????????????????????????????????NMR ??????????Pyrrolidone carboxyl peptidase????????????????????????????? 43????2005? 11? 23??25???????????????? 15)  ?????????????????????????????????????????????????????????????????? 43????2005? 11? 23??25???????????????? 16)  ?? ?????????????????????????????? 43????2005? 11? 23??25???????????????? 17)  Nakano T., Hatanaka Y., Mori Y., Kakuda H. :Homolytic cleavage O-O bond in organic Hydroperoxide accompanying the reduction of water-soluble hemin in the presence of MBTH in aqueous media. The 2005 International Chemical Congress of Pacific Basin Societies, 2005, 12, Honolulu.  ? ??? 1)  ??????????????????????????????????????????????? 3 ? ???? 3000???????????????2004, 11? 25???????? ??????????????? 2)  ???????????????????????????????????????????????????? GBP?????????????????????????????????????????????????????????2004?12? 20??21????? ???????? ?????????????? 3)  Matsuura A., Mizuguchi M., Nabeshima Y., Kawano K. :Effects of the stabilization of the molten globule state on the folding mechanism of α-lactalbumin. ??????????????????????????? 2???????????2005? 3? 17??18????????????? 4)  Takeuchi M., Mizuguchi M., Yutani K., Kawano K. :Protein structure at the first stage of folding reaction. ??????????????????????????? 2???????????2005? 3? 17??18????????????? 5)  ?????????????????????????????????????????? ?????????????????????2005? 5? 26?(?)?27?(?), ??????????.  6)  ??????????????????????????????????2005, 9? 5????????? 

薬剤設計学　構造生物学研究室

????? Physical Pharmacy ???????? Structural Biology  ???   ?? ??  Mineyuki Mizuguchi ? ?   ?  ??  Yoshihiro Mori ? ?   ?? ??  Hiroyuki Shinoda  ? ? ? 1) ??????????SBO 23  ???????????????????????????????????????????. ????????????? 2 ????? III. ??????????????????????????, ??????, ??, 127-132, 2006.  ? ? ? 1) Sato, T., Ando, Y., Susuki, S., Mikami, F., Ikemizu, S., Nakamura, M., Suhr, O., Anraku, M., Kai, T., Suico, M. A., Shuto, T., Mizuguchi, M., Yamagata, Y. and Kai, H. Chromium (III) ion and thyroxine cooperate to stabilize the transthyretin tetramer and suppress in vitro amyloid fibril formation. FEBS Lett. 580: 491-496, 2006. 2) Marchesini, G. R., Meulenberg, E., Haasnoot, W., Mizuguchi, M. and Irth, H. Biosensor recognition of thyroid-disrupting chemicals using transport proteins. Anal Chem, 78: 1107-1114, 2006. 3) Shinoda, H., Mori, Y. and Mizuguchi, M. Reinvestigation into the ring-opening process of monochloroethylene oxide by quantum chemical calculations. Int J Quantum Chem, 106: 952-959, 2006. 4) Tada, M., Shinohara, Y., Kato, I., Hiraga, K., Aizawa, T., Demura, M., Mori, Y., Shinoda H., Mizuguchi, M. and Kawano, K. Preparation and observation of fresh-frozen sections of the green fluorescent protein transgenic mouse head. Acta Histochem Cytochem, 39: 31-34, 2006. 5) Watanabe, S., Tada, M., Aizawa, T., Yoshida, M., Sugaya, T., Taguchi, M., Kouno, T., Nakamura, T., Mizuguchi, M., Demura, M., Hayakawa, Y. and Kawano, K. N-Terminal mutational analysis of the interaction between growth-blocking peptide (GBP) and receptor of insect immune cells. Protein Pept. Lett, 13: 815-822, 2006. 6) Mori Y., Shinoda H., Nakano T., Takasu R., and Kitagawa T.: Laser-induced formation of pyrenyloxy radical from 1-hydroxypyrene and further oxidation: Micellar effects. J. Photochem. Photobiol. A: Chemistry, 182: 168-173, 2006.  ? ???? 1) ????? ????????? ????? ?????? ?????????? ?????Pyrrolidone carboxyl peptidase? C????????????????????????????? 6??????????2006?4???? 2) ????????????????????????????????????????????????? roadblock? DL2A??????? 6??????????2006?4???? 3) ????????????????????????????????????????????????????????????? 6??????????2006?4???? 4) ????????????????????????????????????????????????????????????????? tachystatin B????????? 6??????????2006?4???? 5) ?????????????????????????????? CIDNP??????????????? 6??????????2006?4???? 6) ??????????????????????????????????????????? GBP? N-?????????????????????????????????? 6??????????2006?4???? 7) Iimura, S., Umezaki, T., Takeuchi, M., Mizuguchi, M., Ogasahara, K., Yagi, H., Akutsu, H., Noda, Y., Segawa, S. and Yutani, K. Role of the C-terminal α-helix in folding and stability of pyrrolidone carboxyl peptidase from a hyperthermophile. 20th Annual Symposium of the Protein Society & 20th Anniversary Celebration. August 5-9, 2006, San Diego, CA. USA. 8) Kouno, T., Mizuguchi, M., Mori, Y., Tanida, I., Ueno, T., Kominami, E. and Kawano, K. Observation of protein binding to membrane with photo-CIDNP technique. XXIIND International Conference on Magnetic Resonance in Biological Systems. August 20-25, 2006, Göttingen, Germany.   9) Saito, S. Aizawa, T. Kamiya, M. Kumaki, Y. Mizuguchi, M. Takiya, S. *Demura, M. and Kawano, K. Solution structure of DNA-binding units of FMBP-1 and the role of the four units in DNA-binding. XXIIND International Conference on Magnetic Resonance in Biological Systems. August 20-25, 2006, Göttingen, Germany.   10) Soejima, M., Mizuguchi, M., Igarashi, Y., Nabeshima, Y., Mori, Y., Shinoda, H. and Kawano, K. Transthyretin mutations and neurotoxicity. Fifth East Asian Biophysics Symposium & Forty-Fourth Annual Meeting of the Biophysical Society of Japan, November 12-16, 2006, Okinawa Convention Center. 11) Nagai, Y., Mizuguchi, M., Sitoh, D., Takeuchi, M., Nabeshima, Y., Mori, Y., Shinoda, H. and Kawano, K. Proline-scanning mutagenesis of transthyretin and its effect on the intermediate structure. Fifth East Asian Biophysics Symposium & Forty-Fourth Annual Meeting of the Biophysical Society of Japan, November 12-16, 2006, Okinawa Convention Center. 12) Takeuchi, M., Mizuguchi, M., Dobashi, M., Mori, Y., Shinoda, H. and Kawano, K. Amyloid fibril formation of a peptide fragment of transthyretin. Fifth East Asian Biophysics Symposium & Forty-Fourth Annual Meeting of the Biophysical Society of Japan, November 12-16, 2006, Okinawa Convention Center. 13) Bak, S., Kamiya, M., Umetsu, Y., Aizawa, T., Kouno, T., Mizuguchi, M., Kumaki, Y., Demura, M. and Kawano, K. Fast backbone amide assignment of 15N-HSQC spectrum. Fifth East Asian Biophysics Symposium & Forty-Fourth Annual Meeting of the Biophysical Society of Japan, November 12-16, 2006, Okinawa Convention Center. 14) Sugita, K., Ohkubo, T., Kamiya, M., Kamijima, T., Shimamoto, S., Tatami, F., Aizawa, T., Mizuguchi, M.,. Kawabata, S., Demura, M. and Kawano, K. Structure of tachyplesin I bound to dodecylphosphocholine micelles. Fifth East Asian Biophysics Symposium & Forty-Fourth Annual Meeting of the Biophysical Society of Japan, November 12-16, 2006, Okinawa Convention Center. Fifth East Asian Biophysics Symposium & Forty-Fourth Annual Meeting of the Biophysical Society of Japan, November 12-16, 2006, Okinawa Convention Center. 15) Umetsu, Y., Aizawa, T., Muto, K., Yamamoto, H., Kamiya, M., Kumaki, Y., Mizuguchi, M., Demura, M., Hayakawa, Y. and Kawano, K. Structure-activity relationships and C-terminal elongation effects of Growth-blocking peptide. Fifth East Asian Biophysics Symposium & Forty-Fourth Annual Meeting of the Biophysical Society of Japan, November 12-16, 2006, Okinawa Convention Center. 16) Iimura, S., Umezaki, T., Takeuchi, M., Mizuguchi, M., Ogasahara, K., Yagi, H., Akutsu, H., Noda, Y., Segawa S. and Yutani K. H/D exchange characterization of the C-terminal α-helix in the denatured state of pyrrolidone carboxyl peptidase from a hyperthermophile. Fifth East Asian Biophysics Symposium & Forty-Fourth Annual Meeting of the Biophysical Society of Japan, November 12-16, 2006, Okinawa Convention Center.  ? ??? 1) ????????????????????????????????????????????????????????????2005?3?????? ??????? 2) Takeuchi M., Mizuguchi M., Kouno T., Ohki S., Yutani K., Kawano K. :NMR investigation of the refolding intermediate of pyrrolidone carboxyl peptidase from a hyperthermophile. ??????????????????????????? 3???????????2006?1????????? ?????????????????????? 3) ??????? dynein light chain??????????? NMR???????. ?????????????????????????????????? ???????????? in???, 2006?2???????????????? 4) ??????????????????????????????????????????????????????????2006?3???????????????????? 5) ????????????????????????????????????? ?????????????????????????????????????????????????????????????????2006?12???????????????????????? 6) ?????????????????????????????????PQBP-1?? C??????? hDim1??????????????????????????????????????????????2006?12???????????????????????? 7) ?????????????????????????????????Gelsolin domain-2? amyloid beta-peptide???????????????????????????????????????????2006?12???????????????????????? 8) ?????????????????????????????????Amyloid beta-peptide???????????????????????????????????????????????2006?12???????????????????????? 9) Takeuchi, M., Mizuguchi, M., Nabeshima, Y., Yutani, K., Kawano, K. The intermediate structure of pyrrolidone carboxyl peptidase studied by site-directed spin labeling and NMR. ??????????????????????????? 4???????????2006?12?????????????? 

薬剤設計学構造生物学研究室

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Structural Biology, Physical Pharmacy

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