Prevalence of Kaposi’s sarcoma-associated herpesvirus in Uygur and Han populations from the Urumqi and Kashgar regions of Xinjiang, China

Kaposi’s sarcoma-associated herpesvirus (KSHV) is the infectious etiologic agent associated with Kaposi’s sarcoma (KS), primary effusion lymphoma, and multicentric Castleman disease. It has been shown that high KSHV prevalence and high incidence of both classic KS and AIDSassociated KS are found mostly among people of Uygur ethnicity in Xinjiang, while people of Han ethnicity in Xinjiang have a higher KSHV seroprevalence than those of other Han populations in mainland China. However, it is still unclear why there is such geographical and population variation in KSHV distribution in China. In this work, we focused on the populations in the Kashgar region and Urumqi area, where a total of 1294 research subjects were randomly selected to investigate the potential correlation between KSHV prevalence and different ethnicities in endemic areas of Xinjiang, and to determine risk factors that may affect KSHV infection rates or KS incidence. We identified a high seroprevalence of KSHV and high peripheral blood DNA infection in the general Uygur and Han populations in both Urumqi and Kashgar regions of Xinjiang, and determined that advancing age, low education level, and stationary population status affect KSHV infection rates. Further, KSHV-positive Uygur participants were shown to have higher prevalence of neutralizing antibodies and neutralizing antibody titers than KSHV-positive Han participants

Projected Spatiotemporal Dynamics of Drought under Global Warming in Central Asia

Drought, one of the most common natural disasters that have the greatest impact on human social life, has been extremely challenging to accurately assess and predict. With global warming, it has become more important to make accurate drought predictions and assessments. In this study, based on climate model data provided by the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP), we used the Palmer Drought Severity Index (PDSI) to analyze and project drought characteristics and their trends under two global warming scenarios—1.5 °C and 2.0 °C—in Central Asia. The results showed a marked decline in the PDSI in Central Asia under the influence of global warming, indicating that the drought situation in Central Asia would further worsen under both warming scenarios. Under the 1.5 °C warming scenario, the PDSI in Central Asia decreased first and then increased, and the change time was around 2080, while the PDSI values showed a continuous decline after 2025 in the 2.0 °C warming scenario. Under the two warming scenarios, the spatial characteristics of dry and wet areas in Central Asia are projected to change significantly in the future. In the 1.5 °C warming scenario, the frequency of drought and the proportion of arid areas in Central Asia were significantly higher than those under the 2.0 °C warming scenario. Using the Thornthwaite (TH) formula to calculate the PDSI produced an overestimation of drought, and the Penman–Monteith (PM) formula is therefore recommended to calculate the index

Active Tectonics in Southern Xinjiang, China: Analysis of Terrace Riser and Normal Fault Scarp Degradation Along the Hotan-Qira Fault System

The northern piedmont of the western Kunlun mountains (Xinjiang, China) is marked at its easternmost extremity, south of the Hotan-Qira oases, by a set of normal faults trending N50E for nearly 70 km. Conspicuous on Landsat and SPOT images, these faults follow the southeastern border of a deep flexural basin and may be related to the subsidence of the Tarim platform loaded by the western Kunlun northward overthrust. The Hotan-Qira normal fault system vertically offsets the piedmont slope by 70 m. Highest fault scarps reach 20 m and often display evidence for recent reactivations about 2 m high. Successive stream entrenchments in uplifted footwalls have formed inset terraces. We have leveled topographic profiles across fault scarps and transverse abandoned terrace risers. The state of degradation of each terrace edge has been characterized by a degradation coefficient τ, derived by comparison with analytical erosion models. Edges of highest abandoned terraces yield a degradation coefficient of 33 ± 4 m^2. Profiles of cumulative fault scarps have been analyzed in a similar way using synthetic profiles generated with a simple incremental fault scarp model. The analysis shows that (1) rate of fault slip remained essentially constant since the aggradation of the piedmont surface and (2) the occurrence of inset terraces was synchronous at all studied sites, suggesting a climate-driven terrace formation. Observation of glacial and periglacial geomorphic features along the northern front of the western Kunlun range indicates that the Qira glaciofluvial fan emplaced after the last glacial maximum, during the retreat of the Kunlun glaciers (12–22 ka). The age of the most developed inset terrace in uplifted valleys is inferred to be 10 ± 3 ka, coeval with humid climate pulses of the last deglaciation. The mass diffusivity constant (k=τ/T, being time B.P.) in the Hotan region is determined to be 3.3 ± 1.4 m^2/10^3 years, consistent with other estimates in similar climatic and geologic environments of western China. These results imply a minimum rate for the Tarim subsidence of 3.5 ± 2 mm/yr. If Western Kunlun overthrusts the Tarim platform on a crustal ramp dipping 40°–45° to the south, it would absorb at least 4.5 ± 3 mm/yr of convergence between western Tibet and Tarim