A novel multi-component generalization of the short pulse equation and its multisoliton solutions

We propose a novel multi-component system of nonlinear equations that generalizes the short pulse (SP) equation describing the propagation of ultra-short pulses in optical fibers. By means of the bilinear formalism combined with a hodograph transformation, we obtain its multi-soliton solutions in the form of a parametric representation. Notably, unlike the determinantal solutions of the SP equation, the proposed system is found to exhibit solutions expressed in terms of pfaffians. The proof of the solutions is performed within the framework of an elementary theory of determinants. The reduced 2-component system deserves a special consideration. In particular, we show by establishing a Lax pair that the system is completely integrable. The properties of solutions such as loop solitons and breathers are investigated in detail, confirming their solitonic behavior. A variant of the 2-component system is also discussed with its multisoliton solutions.Comment: Minor correction

The Lyapunov stability of the N-soliton solutions in the Lax hierarchy of the Benjamin-Ono equation

The Lyapunov stability is established for the N-soliton solutions in the Lax hierarchy of the Benjamin-Ono (BO) equation. We characterize the N-soliton profiles as critical points of certain Lyapunov functional. By using several results derived by the inverse scattering transform of the BO equation, we demonstarate the convexity of the Lyapunov functional when evaluated at the N-soliton profiles. From this fact, we deduce that the N-soliton solutions are energetically stable.Comment: To appear in Journa of Mathematical Physic

REVITALISASI PENDIDIKAN KEWARGANEGARAAN MELALUI MODEL BELAJAR PRAKTIK BELAJAR KEWARGANEGARAAN (PROIECT CITIZEN)

In addition to civic knowledge, Project Citizen aims to foster the skills necessary for citizenship kewarganegaraan democracy. Various aspects of the program and student interaction with their classmates, government representatives, and non-governmental organisations at the time of intensive research on community problems allows the students have many opportunities to apply the intellectual skills and abilities to participate. Furthermore, through their participation in Project Citizen students have the opportunity to develop a variety of civic character of a democratic society such as the meaning of political values, political interests, political tolerance,commitment to the exercise democratic citizenship, commitment to civic responsibility, commitment to constitutionalism and the tendency to participate. The characteristics of these traits, which can be developed through Project Citizen,encourage responsible participation and effective by the citizens in a democracy which they run

Perivascular mast cells regulate vein graft neointimal formation and remodeling

Objective. Emerging evidence suggests an important role for mast cells in vein graft failure. This study addressed the hypothesis that perivascular mast cells regulate in situ vascular inflammatory and proliferative responses and subsequent vein graft neointimal lesion formation, using an optimized local mast cell reconstitution method. Methods and Results. Neointimal hyperplasia was induced by insertion of a vein graft into the right carotid artery in wild type and mast cell deficient KitW−sh/W−sh mice. In some experiments, mast cells were reconstituted systemically (tail vein injection of bone marrow-derived mast cells) or locally (directly into the right neck area) prior to vein grafting. Vein graft neointimal lesion formation was significantly (P < 0.05) reduced in KitW−sh/W−sh mice. Mast cell deficiency reduced the number of proliferating cells, and inhibited L-selectin, CCL2, M-CSF and MIP-3α expression in the vein grafts. Local but not systemic mast cell reconstitution restored a perivascular mast cell population that subsequently promoted neointimal formation in mast cell deficient mice. Conclusion. Our data demonstrate that perivascular mast cells play a key role in promoting neointima formation by inducing local acute inflammatory and proliferative responses. These results suggest that ex vivo intraoperative targeting of mast cells may have therapeutic potential for the prevention of pathological vein graft remodeling

The incidence of portal vein thrombosis at liver transplantation

The incidence of portal vein thrombosis was examined in 885 patients who received orthotopic liver transplantations for various end‐stage liver diseases between 1989 and 1990. The thrombosis was classified into four grades. Grade 1 was thrombosis of intrahepatic portal vein branches, grade 2 was thrombosis of the right or left portal branch or at the bifurcation, grade 3 was partial obstruction of the portal vein trunk, and grade 4 was complete obstruction of the portal vein trunk. Among the 849 patients without previous portosystemic shunt, 14 patients (1.6%) had grade 1, 27 patients (3.2%) had grade 2, 27 patients (3.2%) had grade 3 and 49 patients (5.8%) had grade 4 portal vein thrombosis. The incidence of portal vein thrombosis was highest (34.8%) in the patients with hepatic malignancy in the cirrhotic liver, followed by those with Budd‐Chiari syndrome (22.2%) and postnecrotic cirrhosis of various causes (15.7%). The patients with encephalopathy, ascites, variceal bleeding, previous splenectomy and small liver had significantly higher incidences of portal vein thrombosis than the others. The total incidence of portal vein thrombosis among the 36 patients with previous portosystemic shunt was 38.9%, which was significantly higher than that (13.8%) of those without shunt. (HEPATOLOGY 1992;16;1195–1198.) Copyright © 1992 American Association for the Study of Liver Disease

Rare External Jugular Vein Pseudoaneurysm

External jugular vein pseudoaneurysm is a very rare cause of a neck mass due to the low pressure venous system. This case demonstrates a 27-year-old female who presented to the emergency department with a non-tender, compressible, left-sided neck mass that enlarged with valsalva and talking, and intermittent paresthesias. Upon workup, she was diagnosed with an external jugular vein pseudoaneurysm. Complications of this diagnosis are mentioned in the literature; however, most patients with an external jugular vein pseudoaneurysm or aneurysm can be safely discharged with close follow-up with a vascular surgeon

Factors influencing in vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA.

Long-term expression of coagulation factor IX (FIX) has been observed in murine and canine models following administration of recombinant adeno-associated viral (rAAV) vectors into either the portal vein or muscle. These studies were designed to evaluate factors that influence rAAV-mediated FIX expression. Stable and persistent human FIX (hFIX) expression (> 22 weeks) was observed from 4 vectors after injection into the portal circulation of immunodeficient mice. The level of expression was dependent on promoter with the highest expression, 10% of physiologic levels, observed with a vector containing the cytomegalovirus (CMV) enhancer/beta-actin promoter complex (CAGG). The kinetics of expression after injection of vector particles into muscle, tail vein, or portal vein were similar with hFIX detectable at 2 weeks and reaching a plateau by 8 weeks. For a given dose, intraportal administration of rAAV CAGG-FIX resulted in a 1.5-fold or 4-fold higher level of hFIX compared to tail vein or intramuscular injections, respectively. Polymerase chain reaction analysis demonstrated predominant localization of the rAAV FIX genome in liver and spleen after tail vein injection with a higher proportion in liver after portal vein injection. Therapeutic levels of hFIX were detected in the majority of immunocompetent mice (21 of 22) following intravenous administration of rAAV vector without the development of anti-hFIX antibodies, but hFIX was not detected in 14 immunocompetent mice following intramuscular administration, irrespective of strain. Instead, neutralizing anti-hFIX antibodies were detected in all the mice. These observations may have important implications for hemophilia B gene therapy with rAAV vectors