Unconventional machine learning of genome-wide human cancer data

Recent advances in high-throughput genomic technologies coupled with exponential increases in computer processing and memory have allowed us to interrogate the complex aberrant molecular underpinnings of human disease from a genome-wide perspective. While the deluge of genomic information is expected to increase, a bottleneck in conventional high-performance computing is rapidly approaching. Inspired in part by recent advances in physical quantum processors, we evaluated several unconventional machine learning (ML) strategies on actual human tumor data. Here we show for the first time the efficacy of multiple annealing-based ML algorithms for classification of high-dimensional, multi-omics human cancer data from the Cancer Genome Atlas. To assess algorithm performance, we compared these classifiers to a variety of standard ML methods. Our results indicate the feasibility of using annealing-based ML to provide competitive classification of human cancer types and associated molecular subtypes and superior performance with smaller training datasets, thus providing compelling empirical evidence for the potential future application of unconventional computing architectures in the biomedical sciences

Stochastic Spin-Orbit Torque Devices as Elements for Bayesian Inference

Probabilistic inference from real-time input data is becoming increasingly popular and may be one of the potential pathways at enabling cognitive intelligence. As a matter of fact, preliminary research has revealed that stochastic functionalities also underlie the spiking behavior of neurons in cortical microcircuits of the human brain. In tune with such observations, neuromorphic and other unconventional computing platforms have recently started adopting the usage of computational units that generate outputs probabilistically, depending on the magnitude of the input stimulus. In this work, we experimentally demonstrate a spintronic device that offers a direct mapping to the functionality of such a controllable stochastic switching element. We show that the probabilistic switching of Ta/CoFeB/MgO heterostructures in presence of spin-orbit torque and thermal noise can be harnessed to enable probabilistic inference in a plethora of unconventional computing scenarios. This work can potentially pave the way for hardware that directly mimics the computational units of Bayesian inference

Why Computation?

This paper reviews my personal inclinations and fascination with the area of unconventional computing. Computing can be perceived as an inscription in a "Rosetta Stone," one category akin to physics, and therefore as a form of comprehension of nature: at least from a purely syntactic perspective, to understand means to be able to algorithmically (re)produce. I also address the question of why there is computation, and sketch a research program based on primordial chaos, out of which order and even self-referential perception emerges by way of evolution.Comment: 4 pages, 1 figure, invited contribution to "Paths to Unconventional Computing" for a special issue on "Integral Biomathics

What Makes a Computation Unconventional?

A coherent mathematical overview of computation and its generalisations is described. This conceptual framework is sufficient to comfortably host a wide range of contemporary thinking on embodied computation and its models.Comment: Based on an invited lecture for the 'Symposium on Natural/Unconventional Computing and Its Philosophical Significance' at the AISB/IACAP World Congress 2012, University of Birmingham, July 2-6, 201