Laser opacity in underdense preplasma of solid targets due to quantum electrodynamics effects

We investigate how next-generation laser pulses at 10 PW $-$ 200 PW interact with a solid target in the presence of a relativistically underdense preplasma produced by amplified spontaneous emission (ASE). Laser hole boring and relativistic transparency are strongly restrained due to the generation of electron-positron pairs and $\gamma$-ray photons via quantum electrodynamics (QED) processes. A pair plasma with a density above the initial preplasma density is formed, counteracting the electron-free channel produced by the hole boring. This pair-dominated plasma can block the laser transport and trigger an avalanche-like QED cascade, efficiently transfering the laser energy to photons. This renders a 1-$\rm\mu m$-scalelength, underdense preplasma completely opaque to laser pulses at this power level. The QED-induced opacity therefore sets much higher contrast requirements for such pulse in solid-target experiments than expected by classical plasma physics. Our simulations show for example, that proton acceleration from the rear of a solid with a preplasma would be strongly impaired.Comment: 5 figure

Validation of a blood plasma separation system by biomarker detection

A microfluidic system was developed for blood plasma separation at high flow rate. This system uses only hydrodynamic forces to separate plasma from whole blood. The microfluidic network features a series of constrictions and bifurcations to enhance the product yield and purity. A maximum purity efficiency of 100% is obtained on blood with entrance hematocrit level up to 30% with a flow rate of 2 mL h-1. Flow cytometry was performed on the extracted plasma to evaluate the separation efficiency and to assess cell damage. A core target of this study was the detection of cell-free DNA from the on-chip extracted plasma. To this effect, PCR was successfully carried out off-chip on the cell-free DNA present in the plasma extracted on-chip. A house-keeping gene sequence (GAPDH) was amplified without the need for a purification after the separation, thereby showing the high quality of the plasma sample. The resulting data suggests that the system can be used as a preliminary module of a total analysis system for cell-free DNA detection in human plasma. © 2010 The Royal Society of Chemistry.</p

GigaGauss solenoidal magnetic field inside of bubbles excited in under-dense plasma

Magnetic fields have a crucial role in physics at all scales, from astrophysics to nanoscale phenomena. Large fields, constant or pulsed, allow investigation of material in extreme conditions, opening up plethora of practical applications based on ultra-fast process, and studying phenomena existing only in exotic astro-objects like neutron stars or pulsars. Magnetic fields are indispensable in particle accelerators, for guiding the relativistic particles along a curved trajectory and for making them radiate in synchrotron light sources and in free electron lasers. In the presented paper we propose a novel and effective method for generating solenoidal quasi-static magnetic field on the GigaGauss level and beyond, in under-dense plasma, using screw-shaped high intensity laser pulses. In comparison with already known techniques which typically rely on interaction with over-dense or solid targets, where radial or toroidal magnetic field localized at the stationary target were generated, our method allows to produce gigantic solenoidal fields, which is co-moving with the driving laser pulse and collinear with accelerated electrons. The solenoidal field is quasi-stationary in the reference frame of the laser pulse and can be used for guiding electron beams and providing synchrotron radiation beam emittance cooling for laser-plasma accelerated electron and positron beams, opening up novel opportunities for designs of the light sources, free electron lasers, and high energy colliders based on laser plasma acceleration.Comment: 15 pages, 9 figures. Main text (without abstract, References and Appendix): 12 page

A Role of the Bile Salt Receptor FXR in Atherosclerosis

This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism. At the molecular level, bile salts regulate lipid and energy homeostasis mainly via the bile salt receptors FXR and TGR5. Activation of FXR has been shown to improve plasma lipid profiles, whereas Fxr(-/-) mice have increased plasma triglyceride and very-low-density lipoprotein levels. Nevertheless, high-density lipoprotein cholesterol levels are increased in these mice, suggesting that FXR has both anti-and proatherosclerotic properties. Interestingly, there is increasing evidence for a role of FXR in "nonclassical" bile salt target tissues, eg, vasculature and macrophages. In these tissues, FXR has been shown to influence vascular tension and regulate the unloading of cholesterol from foam cells, respectively. Recent publications have provided insight into the antiinflammatory properties of FXR in atherosclerosis. Bile salt signaling via TGR5 might regulate energy homeostasis, which could serve as an attractive target to increase energy expenditure and weight loss. Interventions aiming to increase cholesterol turnover (eg, by bile salt sequestration) significantly improve plasma lipid profiles and diminish atherosclerosis in animal models. Bile salt metabolism and bile salt signaling pathways represent attractive therapeutic targets for the treatment of atherosclerosi

Characterisation of the L-mode Scrape Off Layer in MAST: decay lengths

This work presents a detailed characterisation of the MAST Scrape Off Layer in L-mode. Scans in line averaged density, plasma current and toroidal magnetic field were performed. A comprehensive and integrated study of the SOL was allowed by the use of a wide range of diagnostics. In agreement with previous results, an increase of the line averaged density induced a broadening of the midplane density profile.Comment: 30 pages, 11 figure