Performance Comparison of Knowledge-Based Dose Prediction Techniques Based on Limited Patient Data.

PurposeThe accuracy of dose prediction is essential for knowledge-based planning and automated planning techniques. We compare the dose prediction accuracy of 3 prediction methods including statistical voxel dose learning, spectral regression, and support vector regression based on limited patient training data.MethodsStatistical voxel dose learning, spectral regression, and support vector regression were used to predict the dose of noncoplanar intensity-modulated radiation therapy (4π) and volumetric-modulated arc therapy head and neck, 4π lung, and volumetric-modulated arc therapy prostate plans. Twenty cases of each site were used for k-fold cross-validation, with k = 4. Statistical voxel dose learning bins voxels according to their Euclidean distance to the planning target volume and uses the median to predict the dose of new voxels. Distance to the planning target volume, polynomial combinations of the distance components, planning target volume, and organ at risk volume were used as features for spectral regression and support vector regression. A total of 28 features were included. Principal component analysis was performed on the input features to test the effect of dimension reduction. For the coplanar volumetric-modulated arc therapy plans, separate models were trained for voxels within the same axial slice as planning target volume voxels and voxels outside the primary beam. The effect of training separate models for each organ at risk compared to all voxels collectively was also tested. The mean squared error was calculated to evaluate the voxel dose prediction accuracy.ResultsStatistical voxel dose learning using separate models for each organ at risk had the lowest root mean squared error for all sites and modalities: 3.91 Gy (head and neck 4π), 3.21 Gy (head and neck volumetric-modulated arc therapy), 2.49 Gy (lung 4π), and 2.35 Gy (prostate volumetric-modulated arc therapy). Compared to using the original features, principal component analysis reduced the 4π prediction error for head and neck spectral regression (-43.9%) and support vector regression (-42.8%) and lung support vector regression (-24.4%) predictions. Principal component analysis was more effective in using all/most of the possible principal components. Separate organ at risk models were more accurate than training on all organ at risk voxels in all cases.ConclusionCompared with more sophisticated parametric machine learning methods with dimension reduction, statistical voxel dose learning is more robust to patient variability and provides the most accurate dose prediction method

Doubly Optimized Calibrated Support Vector Machine (DOC-SVM): an algorithm for joint optimization of discrimination and calibration.

Historically, probabilistic models for decision support have focused on discrimination, e.g., minimizing the ranking error of predicted outcomes. Unfortunately, these models ignore another important aspect, calibration, which indicates the magnitude of correctness of model predictions. Using discrimination and calibration simultaneously can be helpful for many clinical decisions. We investigated tradeoffs between these goals, and developed a unified maximum-margin method to handle them jointly. Our approach called, Doubly Optimized Calibrated Support Vector Machine (DOC-SVM), concurrently optimizes two loss functions: the ridge regression loss and the hinge loss. Experiments using three breast cancer gene-expression datasets (i.e., GSE2034, GSE2990, and Chanrion's datasets) showed that our model generated more calibrated outputs when compared to other state-of-the-art models like Support Vector Machine (p=0.03, p=0.13, and p<0.001) and Logistic Regression (p=0.006, p=0.008, and p<0.001). DOC-SVM also demonstrated better discrimination (i.e., higher AUCs) when compared to Support Vector Machine (p=0.38, p=0.29, and p=0.047) and Logistic Regression (p=0.38, p=0.04, and p<0.0001). DOC-SVM produced a model that was better calibrated without sacrificing discrimination, and hence may be helpful in clinical decision making

Regression-based Multi-View Facial Expression Recognition

We present a regression-based scheme for multi-view facial expression recognition based on 2-D geometric features. We address the problem by mapping facial points (e.g. mouth corners) from non-frontal to frontal view where further recognition of the expressions can be performed using a state-of-the-art facial expression recognition method. To learn the mapping functions we investigate four regression models: Linear Regression (LR), Support Vector Regression (SVR), Relevance Vector Regression (RVR) and Gaussian Process Regression (GPR). Our extensive experiments on the CMU Multi-PIE facial expression database show that the proposed scheme outperforms view-specific classifiers by utilizing considerably less training data

European exchange trading funds trading with locally weighted support vector regression

In this paper, two different Locally Weighted Support Vector Regression (wSVR) algorithms are generated and applied to the task of forecasting and trading five European Exchange Traded Funds. The trading application covers the recent European Monetary Union debt crisis. The performance of the proposed models is benchmarked against traditional Support Vector Regression (SVR) models. The Radial Basis Function, the Wavelet and the Mahalanobis kernel are explored and tested as SVR kernels. Finally, a novel statistical SVR input selection procedure is introduced based on a principal component analysis and the Hansen, Lunde, and Nason (2011) model confidence test. The results demonstrate the superiority of the wSVR models over the traditional SVRs and of the v-SVR over the ε-SVR algorithms. We note that the performance of all models varies and considerably deteriorates in the peak of the debt crisis. In terms of the kernels, our results do not confirm the belief that the Radial Basis Function is the optimum choice for financial series

Estimating Probabilities of Default With Support Vector Machines

This paper proposes a rating methodology that is based on a non-linear classification method, the support vector machine, and a non-parametric technique for mapping rating scores into probabilities of default. We give an introduction to underlying statistical models and represent the results of testing our approach on German Bundesbank data. In particular we discuss the selection of variables and give a comparison with more traditional approaches such as discriminant analysis and the logit regression. The results demonstrate that the SVM has clear advantages over these methods for all variables tested.Bankruptcy, Company rating, Default probability, Support vector machines.

Oil PVT characterisation using ensemble systems

In reservoir engineering, there is always a need to estimate crude oil Pressure, Volume and Temperature (PVT) properties for many critical calculations and decisions such as reserve estimate, material balance design and oil recovery strategy, among others. Empirical correlation are often used instead of costly laboratory experiments to estimate these properties. However, these correlations do not always give sufficient accuracy. This paper develops ensemble support vector regression and ensemble regression tree models to predict two important crude oil PVT properties: bubblepoint pressure and oil formation volume factor at bubblepoint. The developed ensemble models are compared with standalone support vector machine (SVM) and regression tree models, and commonly used empirical correlations .The ensemble models give better accuracy when compared to correlations from the literature and more consistent results than the standalone SVM and regression tree models