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New homogenization approaches for stochastic transport through heterogeneous media
The diffusion of molecules in complex intracellular environments can be
strongly influenced by spatial heterogeneity and stochasticity. A key challenge
when modelling such processes using stochastic random walk frameworks is that
negative jump coefficients can arise when transport operators are discretized
on heterogeneous domains. Often this is dealt with through homogenization
approximations by replacing the heterogeneous medium with an
homogeneous medium. In this work, we present a new class
of homogenization approximations by considering a stochastic diffusive
transport model on a one-dimensional domain containing an arbitrary number of
layers with different jump rates. We derive closed form solutions for the th
moment of particle lifetime, carefully explaining how to deal with the internal
interfaces between layers. These general tools allow us to derive simple
formulae for the effective transport coefficients, leading to significant
generalisations of previous homogenization approaches. Here, we find that
different jump rates in the layers gives rise to a net bias, leading to a
non-zero advection, for the entire homogenized system. Example calculations
show that our generalized approach can lead to very different outcomes than
traditional approaches, thereby having the potential to significantly affect
simulation studies that use homogenization approximations.Comment: 9 pages, 2 figures, accepted version of paper published in The
Journal of Chemical Physic
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