Discovery of Diffuse Hard X-Ray Emission from the Vicinity of PSR J1648-4611 with Suzaku

We observed the pulsar PSR J1648-4611 with Suzaku. Two X-ray sources, Suzaku J1648-4610 (Src A) and Suzaku J1648-4615 (Src B), were found in the field of view. Src A is coincident with the pulsar PSR J1648-4611, which was also detected by the Fermi Gamma-ray Space Telescope. A hard-band image indicates that Src A is spatially extended. We found point sources in the vicinity of Src A by using a Chandra image of the same region, but the point sources have soft X-ray emission and cannot explain the hard X-ray emission of Src A. The hard-band spectrum of Src A can be reproduced by a power-law model with a photon index of 2.0^{+0.9}_{-0.7}. The X-ray flux in the 2-10 keV band is 1.4 \times 10^{-13} erg cm^{-2} s^{-1}. The diffuse emission suggests a pulsar wind nebula around PSR J1648-4611, but the luminosity of Src A is much larger than that expected from the spin-down luminosity of the pulsar. Parts of the very-high-energy gamma-ray emission of HESS J1646-458 may be powered by this pulsar wind nebula driven by PSR J1648-4611. Src B has soft emission, and its X-ray spectrum can be described by a power-law model with a photon index of 3.0^{+1.4}_{-0.8}. The X-ray flux in the 0.4-10 keV band is 6.4 \times 10^{-14} erg s^{-1} cm^{-2}. No counterpart for Src B is found in literatures.Comment: Accepted for publication in PASJ Vol.65 No.

Quantifying short-range correlations in nuclei

Background: Short-range correlations (SRC) are an important ingredient of the dynamics of nuclei. Purpose: An approximate method to quantify the magnitude of the two-nucleon (2N) and three-nucleon (3N) short-range correlations and their mass dependence is proposed. Method: The proposed method relies on the concept of the "universality" or "local nuclear character" of the SRC. We quantify the SRC by computing the number of independent-particle model (IPM) nucleon pairs and triples which reveal beyond-mean-field behavior. It is argued that those can be identified by counting the number of nucleon pairs and triples in a zero relative orbital momentum state. A method to determine the quantum numbers of pairs and triples in an arbitrary mean-field basis is outlined. Results: The mass dependence of the 2N and 3N SRC is studied. The predictions are compared to measurements. This includes the ratio of the inclusive inelastic electron scattering cross sections of nuclei to H-2 and He-3 at large values of the Bjorken variable. Corrections stemming from the center-of-mass motion of the pairs are estimated. Conclusions: We find that the relative probability per nucleon for 2N and 3N SRC has a soft dependence with mass number A and that the proton-neutron 2N SRC outnumber the proton-proton (neutron-neutron) 2N SRC. A linear relationship between the magnitude of the EMC effect and the predicted number of proton-neutron SRC pairs is observed. This provides support for the role of local nuclear dynamics on the EMC effect

New data strengthen the connection between Short Range Correlations and the EMC effect

Recently published measurements of the two nucleon short range correlation ($NN$-SRC) scaling factors, $a_2(A/d)$, strengthen the previously observed correlation between the magnitude of the EMC effect measured in electron deep inelastic scattering at $0.35\le x_B\le 0.7$ and the SRC scaling factor measured at $x_B \ge 1$. The new results have improved precision and include previously unmeasured nuclei. The measurements of $a_2(A/d)$ for $^9$Be and $^{197}$Au agree with published predictions based on the EMC-SRC correlation. This paper examines the effects of the new data and of different corrections to the data on the slope and quality of the EMC-SRC correlation, the size of the extracted deuteron IMC effect, and the free neutron structure function. The results show that the linear EMC-SRC correlation is robust and that the slope of the correlation is insensitive to most combinations of corrections examined in this work. This strengthens the interpretation that both $NN$-SRC and the EMC effect are related to high momentum nucleons in the nucleus.Comment: 4 pages, 1 figure. v3: minor changes to respond to PRC referee comments. v2: Minor errors in tabulated data corrected. No change to text or conclusion

FUS-CHOP promotes invasion in myxoid liposarcoma through a SRC/FAK/RHO/ROCK-dependent pathway

Deregulated SRC/FAK signaling leads to enhanced migration and invasion in many types of tumors. In myxoid and round cell liposarcoma (MRCLS), an adipocytic tumor characterized by the expression of the fusion oncogene FUS-CHOP, SRC have been found as one of the most activated kinases. Here we used a cell-of-origin model of MRCLS and an MRCLS cell line to thoroughly characterize the mechanisms of cell invasion induced by FUS-CHOP using in vitro (3D spheroid invasion assays) and in vivo (chicken chorioallantoic membrane model) approaches. FUS-CHOP expression activated SRC-FAK signaling and increased the invasive ability of MRCLS cells. In addition, FAK expression was found to significantly correlate with tumor aggressiveness in sarcoma patient samples. The involvement of SRC/FAK activation in FUS-CHOP–mediated invasion was further confirmed using the SRC inhibitor dasatinib, the specific FAK inhibitor PF-573228, and FAK siRNA. Notably, dasatinib and PF573228 could also efficiently block the invasion of cancer stem cell subpopulations. Downstream of SRC/FAK signaling, we found that FUS-CHOP expression increases the levels of the RHO/ROCK downstream effector phospho-MLC2 (T18/S19) and that this activation was prevented by dasatinib or PF573228. Moreover, the ROCK inhibitor RKI-1447 was able to completely abolish invasion in FUS-CHOP–expressing cells. These data uncover the involvement of SRC/FAK/RHO/ROCK signaling axis in FUS-CHOP–mediated invasion, thus providing a rationale for testing inhibitors of this pathway as potential novel antimetastatic agents for MRCLS treatmentPeer ReviewedPostprint (author's final draft